Pharm 6 Anti-Psychotics

Question 1

D2R blockade SE

Answer 1

Increased Prolactin

Question 2

M blockade SE

Answer 2

Dryness

Question 3

Alpha blockade SE

Answer 3

Orthostatic hypotension & impotence

Tachycardia

Question 4

Antihistamine SE

Answer 4

Sedation

Question 5

Brainstem DA/5-HT blockade SE

Answer 5

Anti-emetic

Question 6

Most frequent SE

Answer 6

Drug induced Parkinsonism

Question 7

Neuroleptic malignant syndrome

Answer 7

Severe muscle contraction, hyperthermia, death

Question 8

Drug properties

Answer 8

Lipophilic (BBB, placenta)
Liver metabolism
90% protein bound

Question 9

AD interaction

Answer 9

Lower metabolism, increased serum levels for both

Question 10

Anticonvulsant interaction

Answer 10

Increase elimination of AP via enzymatic activation

Valproic acid is exception (opposite)

Question 11

Anticholinergic interaction

Answer 11

Elicits cognitive dysfunction

Question 12

Antiarrhythmics

Answer 12

Inhibit CYP450, increase cardiotoxicity

Question 13

Clozapine

Answer 13

Atypical

Indication: Negative symptoms
MOA: D4R antagonist
SE: Agranulocytosis
Need blood tests

Question 14

Risperidone

Answer 14

Atypical

D2R antagonist

SE: Extrapyramidal symptoms & increased prolactin

Question 15

Olanzapine

Answer 15

Atypical

Indication: Negative symptoms
MOA: many R including A2
SE: weight gain

Question 16

Aripiprazole

Answer 16

Atypical

D2R antagonist