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Test 6 > Pharm 3 Mood Stabilizers > Flashcards

Pharm 3 Mood Stabilizers Flashcards

1
Q

Mania via what brain disruption

A

Frontal cortical regulation of subcortical areas

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2
Q

Li mechanism

A

Inositol depletion hypothesis

Block IMPase & IPPae from replenishing IP3

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3
Q

2 cyclase effects

A

Decrease adenylate cyclase (receptor activated)

Increase basal adenylate cyclase & cAMP

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4
Q

Lithium danger

A

Narrow therapeutic window

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5
Q

Li in/out

A

Oral

Excreted in urine
Danger if impaired kidney function

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6
Q

Li reabsorption

A

Renal proximal tubule

Compete with Na - must watch levels

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7
Q

Thiazide, ACE-I effect on Li

A

Deplete Na, increase Li reabsorption

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8
Q

NSAID effect on Li

A

Decrease renal perfusion, increase Li reabsorption

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9
Q

Osmotic diuretic effect on Li

A

Decrease Li reabsorption

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10
Q

Chronic Li toxicity (4)

A

Nephrogenic diabetes insipidus (decreased response to ADH, treat with Amiloride)

Thyroid enlargement
Glomerulopathy
Na retention edema

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11
Q

Li contraindications (2)

A

Renal impairment

Brady-Tachycardia syndrome (sick-sinus)

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12
Q

Li effect on heart

A

Depress sinus node (block ion channels)

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13
Q

Li in pregnancy

A

Crosses placenta, causes Ebsteins malformation

Also in breast milk

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14
Q

Li therapeutic onset

A

1-2 weeks

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15
Q

Benzodiazepine use

A

Control mania before lithium kicks in

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16
Q

Antipsychotic use

A

Maintenance therapy, acute control

17
Q

3 primary anticonvulsants for mania

A

Valproic acid
Carbamazepine
Lamotrigine

18
Q

Anticonvulsant SE

A

Spina Bifida

19
Q

Valproic acid v Lithium

A

Faster onset

Wider therapeutic window

20
Q

Valproic acid MOA

A

Ion channel blocking

Decrease inositol levels & PKC signaling

21
Q

Valproic acid SE

A

Nausea & vomiting

22
Q

Carbamazepine v Li

A

Less efficacy for long term

Good for acute mania

23
Q

Carbamazepine MOA

A

Microsomal enzymes

24
Q

Carbamazepine SE

A

Dizziness, drowsiness, GI

25
Q

Lamotrigine v Li

A

Less useful for acute mania

Good for long term maintenance

Test 6 (18 decks)

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