Neuro I Depression Flashcards
Leading cause of disability in US
Major Depressive Disorder
Dysthymia
Low grade depression for >2 years
Need some good periods
Secondary Mood Disorder
Depression due to other illness
Omega sign
Furrowed brown
-Sign of Melancholic Depression
Melancholic insomnia
Early morning awakening
Non-melancholic mood
Resembles normal sadness
Brain disease
Guaranteed in Melancholic only
Adjustment Disorder
Unusually severe reaction to stress (within 3 months)
Must rule out melancholic depression
Unipolar vs. Bipolar depression
Same heritability
Serotonin transporter gene
Short allele causes depression only if exposed to stress
Depression circadian rhythm problem
Elevated night time temp & heart rate
Depression stress response
Non-suppression of corticosteroid
Depression blood flow MRI changes
Decreased in DLPFC
Increased in Amygdala