Neuro G Dementia

Question 1

Cerebrovascular risk factor 
Personality change 
Dyskinesia 
Bradykinesia 
Visual hallucinations 
Mood change and family history of depression 
Longstanding alcoholism

Answer 1

Vascular dementia 
Frontotemporal dementia
Huntington’s 
Parkinson’s 
Lewy body dementia 
Depressive dementia 
Alcoholic dementia

Question 2

Required tests for dementia

Answer 2

  Imaging studies
  Blood tests
  Urinalysis  
  Electrocardiogram 
  Chest X-rays 
  Genetic studies for HD

Question 3

MMS score below which establishes dementia

Answer 3

20

Question 4

Trail making test domain

Answer 4

Executive function

Question 5

Clock drawing purpose

Answer 5

Screen for Alzheimer’s

Question 6

Differentiation between AD MCI & AD Dementia

Answer 6

Maintaining independence

Question 7

Mean AD survival

Answer 7

10 years

Question 8

AD brain finding

Answer 8

Cortical hypoperfusion, ventricular dilatation, sulcal enlargement

Question 9

AD motor finding

Answer 9

restlessness in stage 2

rigidity in stage 3

Question 10

AD Neurofibrillary tangles & Neuritic plaques

Answer 10

Not unique to AD

Question 11

4 genetic AD risk factors

Answer 11

Family history of Dementia
Down’s syndrome
Presenilin mutation & abnormal APP gene
Apolipoprotein E 4 allele

Question 12

Vascular dementia vs. AD

Answer 12

Stepwise progression
More depression
More functional impairment
Less cognitive impairment
More MRI findings

Question 13

Pick’s disease

Answer 13

Frontotemporal dementia

• Personality, Emotional, Executive problems
• Delusions not common

Question 14

Pick’s disease gene

Answer 14

Tau protein

Question 15

Pick’s disease histology

Answer 15

Pick bodies

No tangles

Question 16

Primary Progressive Dementia

Answer 16

Language
Insidious onset
Acalculia and ideomotor apraxia

Question 17

Lewy Body Dementia

Answer 17

Parkinsonism plus cognitive impairment

Visual hallucinations

Question 18

Lewy Body Dementia neuropathology

Answer 18

Minimal frontal atrophy

Lewy bodies in cortex

Question 19

Lewy Body Dementia gene

Answer 19

Synuclein gene on chromosome 4

Question 20

Parkinson’s Dementia

Answer 20

Bradykinesia
Dopamine loss
Reduce cholinergic in frontal cortex

Question 21

Parkinson’s vs. Lewy body

Answer 21

Tremors

Asymmetric vs. symmetric rigidity

Question 22

Wilson’s Disease

Answer 22

Reversible dementia in very young

Question 23

Wilson’s Disease cause

Answer 23

Chromosome 13 (copper excretion)

Question 24

Wilson’s Disease finding

Answer 24

Copper deposits in:
Liver
Basal Ganglia
Cornea

Question 25

Huntington's Disease

Answer 25

Dominant | CAG

Question 26

Huntington's neuropathology

Answer 26

Atrophy of Caudate and Putamen Sparing of Globus Pallidus

Question 27

Parkinson's vs. Huntington's

Answer 27

Bradykinesia & Masked Facies Depression No chorea

Question 28

Alcoholic Dementia neuropathology

Answer 28

Frontal atrophy

Question 29

Disinhibition

Answer 29

Pick's disease

Question 30

Depression

Answer 30

Parkinson's disease

Question 31

Delusions

Answer 31

Alzheimer's disease

Question 32

Hallucinations

Answer 32

Lewy Body dementia

Question 33

Indifference and apathy

Answer 33

Vascular dementia

Question 34

Vascular Tx

Answer 34

Treat HTN

Question 35

Wilson's Tx

Answer 35

Chelating agent (D-pencillamine)

Question 36

Tx for all dementias

Answer 36

``` Cholinesterase inhibitors (Donepezil) Vitamin E NMDA modulators (Mementine) ```

Question 37

Parkinson's Tx

Answer 37

L-dopa