Pharm Flashcards
Which muscarininc receptor uses a dec in adenyl cyclases as its second messenger?
M2
what drug is used to differentiate a cholinergic crisis from myasthenia gravis?
Edrophonium
what drug causes a gradual loss of choline from the presynaptic nerve terminal by blocking its reuptake?
hemicholium
what is the only site in the body that uses M1 receptors?
stomach
what drug is an M1-specific antispasmodic?
pirenzepine
what is the most potent NMJ blocker and also has no CV side effects?
Doxacurium
what antimuscarinic is used as an inhalant for asthma?
Ipratropium
what is the antidote ofr organophosphate ingestion?
atropine and 2-PAM (pralidoxime)
what is the drug of choice for atropine or TCA overdose?
physostigmine
What is the rate-limiting step for NE synthesis?
tyrosine hydroxylase
what 2 enzymes are blocked by disulfiram?
aldehyde dehydrogenase and dopamine B-hydroxylase
what is the monoamine oxidase B (MAOB) inhibitor?
selegiline
what 2 drugs inhibit the relase of neurotransmitters from storage granules?
- Guanethidine2. Bretylium
what drug blocks intragranular uptake of NE?
reserpine
what 2 drugs, when mixed, can lead to malignant hyperthermia?
- Succinylcholine
2. Halothane (tx is with dantrolene)