PHARM 2 Flashcards
MOA of adenosine
Gs protein mechanism, decreases AV and SA node action
MOA of digoxin
inhibit Na/K/ATPase (improves contractility)
increases parasympathetic tone (vagus)
ade: yellow halos vision, ventricular arrhythmias, gynecomastia, n/v/diarrhea
what drug moa is selective If channel inhibitor (funny channel of SA node)
Ivabradine
what does metronidazole cover? “GET GAP on the METRO”
Giardia
Entamoeba
Trichomonas
Gardnerella
Anaerobes (clost, actinomycetes)
H. PYLORI
what 2 classes of drugs affect GABA A receptor?
- Barbituates: INC DURATION of Cl channel opening
- Benzos: INC FREQUENCY of Cl channel opening
what drug affects GABA B receptor?
Baclofen:
*G inhibitory mechanism= reduce aden. cyclase and cyclic amp
*I inhibition of excitatory NT release= glutamate and aspartate
what 3 anti neoplastic drugs cause peripheral neuropathy
- Platin drugs (carboplatin, cisplatin)- these also cause acoustic nerve damage
- Vincristine- also causes alopecia
- Paclitaxel- also causes alopecia
what anti neoplastic drug causes pulmonary fibrosis
Bleomycin/busulfan
what anti neoplastic drug causes hemorrhagic cystitis/ increases risk of bladder cancer
cyclophosphamide (DNA cross linkage)
paclitaxel, vinBLASTine, 5FU, mercaptopurine, methotrexate, etoposide, irinotecan/topecan all cause what (antineoplastic drugs)
myelosuppression
MOA of aramotase inhibitors (anastrozole and Letrozole) that treat ER+ breast cancer
inhibit peripheral conversion of androgens –> estrogen
(ade: osteoporosis)
MOA of Tamoxifen in treating ER+ breast cancer
selective estrogen receptor modulator (SERM)
-estrogen receptor antagonist in breast
-estrogen receptor agonist in bone/endometrium
ade: DVT, pulmonary embolism, endometrial hyperplasia/endometrial cancer
MOA of trastuzumab in treating HER2+ breast cancer
monoclonal antibody against HER2 (tyrosine kinase receptor)
ADE: dilated cardiomyopathy
what chemo drug targets CD20 and has ADE of PML in patients with JC virus
Rituximab
What chemo drug inhibits phospholipase A2 and NF -kB? ADE: cushing syndrome
Prednisone