Pharm

Question 1

potentiate vs permissive MOA drugs

Answer 1

need drug A (w/ no effects) to enhance drug B (2 + 0 > 2) vs need drug A for full effect of drug B

Question 2

details QISS

Answer 2

a1: mydriasis; ctx urethral sphincter & prostate smooth mm -> urin rtn
a2: dec insulin/lipolysis/release FFA, dec aq humor (brominidine tx open angle)
B1: inc renin
B2: inc insulin (gluconeo, hypoK), lipolysis/FFA, aq humor

Question 3

meds QISS: phenylephrine vs NE vs epi vs dobutamine vs isoprotenerol vs terbutaline & ritodrine

Answer 3

a1, dec edema, reflex brady vs a1>B1 -> reflex brady but inc HR/ctx vs B>a vs B1>B2 vs B1=B2 vs B2 -> relax ut smooth mm & prevent PTL

Question 4

MTX tx vs AE. 5FU AE

Answer 4

tx psoriasis, RA; ectopic/mole, chorioca; malig vs alopecia, mucositis, restrictive lung dz/pulm fib, hep tox, folate defic/megalo, myelosupp/pancyto. diarrhea, photosensitivity, hyperpig, myelosupp/pancyto

Question 5

AE AZA/6MP vs mycophenylate. carbidopa CI?

Answer 5

hepatitis, panc vs GI. Psychotic pts

Question 6

cycloP vs bisulfan vs nitrosurea

Answer 6

hem cystitis -> give MENSA to prevent; AE blad ca, SIADH/hypoNa, infertile/early menopause vs hyperpig, lung tox vs -mustine, streptozocin; for brain tumors b/c lipophlic -> cross BBB but AE neurotox

Question 7

topo I vs II inhibitors

Answer 7

-tecan; AE severe diarrhea; single strand breaks, block G2 & S vs -toposide; AE aloepecia; 2x strand breaks, block G2 & S

Question 8

bleo vs anthracyclines vs actinomycin D

Answer 8

free radicals; pulm & skin tox, aloepecia, stomatitis & mucositis vs -rubicin; DCM -> give dexrazoxone (Fe chelator) to prevent, aloepecia; interchelates DNA vs tx peds tumors, AE aloepecia. all block G2

Question 9

imat vs erlotinib vs son/sun-ib vs vemurafenib

Answer 9

hem/onc; block ckit tyr kinase in GIST vs block EGFR; AE acne, diarrhea vs block VEGF; AE hyperkeratosis/rash, hem vs tx melanoma

Question 10

ritux vs cetuximab vs beva-mab vs alem-mab vs trastuzumab

Answer 10

antiCD20, chimeric ab -> serum sick vs EGFR; AE acne vs VEGF, wet macular degen; AE hem vs antiCD52 vs HER2+ br ca; AE cardiotox

Question 11

glucocorticoids AE

Answer 11

dec T/B, periph eos, fibroblasts, neu adhesion -> neuphilia, BMD
inc gluconeo, glycogen storage, proteo/lipolysis, insulin resistance, Cushing

Question 12

TMP/SMX

Answer 12

inhib dihydrofolate reductase/dihydropterate synthetase. tx UTI, prostatitis, PJP, toxo, nocardia. AE NTD, SJS/TEN, photosensitivity, T4RTA, interstitial nephritis