Micro

Question 1

B anthracis vs cereus toxins

Answer 1

lethal factor -> black eschar, edema factor -> inc cAMP vs emetic factor, diarrhea factor -> inc cAMP

Question 2

clostridium tetani vs botulinum vs perfringens

Answer 2

protease cleave SNARE -> no GABA & gly -> mm spasm vs protease cleave SNARE -> no Ach @ NMJ -> reversible flaccid descending paralysis vs 2x zone hemolysis, alpha toxin/PLC, lecithinase; tx debride gangrene, PCN

Question 3

C diff toxin A vs B

Answer 3

dmging intest brush border, granulocytes vs depol actin; both caused by clinda, tx w/ metronidazole, vanc, fidaxomycin

Question 4

does diphtheria have spores? tx? describe TDAP vax

Answer 4

no. erythromycin, antitoxin. formaldehyde toxoid vax -> humoral immunity

Question 5

tx Kleb/Serratia/Enterobacter. description Kleb

Answer 5

3rd gen ceph, FLQ. nonmotile, has capsule (opposite for both for Serr/Enterobact)

Question 6

S. typhi vs enteridis

Answer 6

gall, ileocecal, M cells/Peyer patch; tx 3rd gen ceph, FLQ vs ileocecal, agglut/Widal test; tx self limiting. both H2S, nonlactose, acid labile

Question 7

EHEC vs EIEC vs ETEC vs EPEC

Answer 7

O157:H7 -> shigella like HUS, 60S vs invades intest mucosa -> dysentery vs heat labile tox/cAMP; stable tox/cGMP vs flattens villi -> prevent absorption

Question 8

ferment: staph aureus vs N meningitidis vs lact vs vibrio

Answer 8

mannitol vs maltose vs E coli, Kleb/Serr/Ent vs sucrose -> orange

Question 9

Myco pneu pathogenesis

Answer 9

attach to resp epith via P1 ag, inhib ciliary action, makes H2O2/ROS, needs chol -> Eaton

Question 10

Coxsackie A vs B

Answer 10

both Enteroviruses, viral endocarditis. aseptic meningitis, hand/foot/mouth dz vs DCM, unilat pleurodynia/Devil’s grip

Question 11

congen rubella vs congen VZV

Answer 11

blueberry rash, cataracts, deaf, jaundice, PDA, pulm sten, radiolucent bone lesions vs dermatome scar, limb hypoplasia, blind

Question 12

rabies

Answer 12

nic AchR postsynaptic; retrograde, replicate in motor neurons, travel to DRG; eos Negri bodies in hippo pyramidal cells & Purk cells; killed vax for active, rabies ig for passive immuniz

Question 13

MAC. sxs reactivated TB

Answer 13

AIDS illness <50. tx macrolides + ethambutol, rifabutin as 3rd agent. cough, night sweats, hemoptysis

Question 14

details CMV

Answer 14

Owl eye inclusions, CMV retinitis for CD4<50, hydrops fetalis