Pernicious Anaemia

Question 1

What is pernicious anaemia

Answer 1

Is a disease in which not enough RBC are produced due to deficiency of vitamin B12

Question 2

Causes of pernicious anaemia

Answer 2

1. In adequate intake of vitamin B12
2. Impaired absorption of vitamin B12 due to intristic factor deficiency
3. Due to the immune system attacking the parietal cells of the stomach

Question 3

Signs and symptoms of pernicious anaemia

Answer 3

Shortness of breath
Chest pains
Pale skin
Weakness
Confusions

Question 4

Laboratory diagnosis of pernicious anaemia

Answer 4

MCV is high
MCHC is normal

Question 5

Tests that are done to diagnose pernicious anaemia

Answer 5

1. Bone marrow biopsy
2. Intrinsic factor deficiency test. Blood is tested for antibodies against intrinsic factors

Question 6

Treatment and management of pernicious anaemia

Answer 6

1. Oral doses of folic acid
2. Can be managed by fbc to measure vitamin b12
3. Blood test to to monitor replacement treatment