Nutrition Anaemia

Question 1

2 divisions of nutrition anaemia

Answer 1

1. Microcytic anaemia (iron deficiency)
2. Megaloblastic anaemia ( vitamin b12/folate)

Question 2

What is megaloblastic anaemia

Answer 2

Is a disorder characterized by defective nuclear maturation caused by impared DNA synthesis

Question 3

What causes megaloblastic anaemia

Answer 3

1. Vitamin B12 and folate deficiency

Question 4

Function of vitamin b12 and folate

Answer 4

They are involved in dna synthesis

Question 5

2 important roles played by vitamin b12

Answer 5

1. Acts as co enzyme for mythyltrasferase
2. Important in conversion of methylmalonyl

Question 6

Vitamin B12 sources

Answer 6

1. Produced by micro-organisms and fungi
2. Present in foods of animal origin

Question 7

What 2 compounds makes up vitamin b12

Answer 7

1. Cobalamin
2. Water soluble

Question 8

What 2 proteins are involved in the transport of vit B12

Answer 8

1. Intrinsic factors
2. Transcbalamins 1,2

Question 9

Explain classes of vitamin B12 deficiency

Answer 9

1. Due to intrinsic factors
   Abnormality of intrinsic factors
   Adult PA
   Total or partial gastrectomy
2. Other factors
   Nutrition (vegan)
   Malabsorption
   Intestinal causes
   Fish tapeworm

Question 10

Where do we obtain folate

Answer 10

1. Green vegetables
2. Absorption through the upper small intestine

Question 11

What are the causes of folate deficiency

Answer 11

1. Nutritional
2. Excessive utilisation
3. Malabsorption

Question 12

What are the lab findings of megaloblastic anaemia

Answer 12

In FBC
1. MCV>95 fl
2. White cell count, platelets and retic count is reduced

In blood firm
Oval macrocytes

Serum vitamin b12 is reduced

Question 13

What the other causes of macrocytosis

Answer 13

1. Alcohol
2. Liver diseases
3. Drugs
4. Pregnancy
5. Smoking