Peptide antigen presentation to T cells II: Immunological/immune Synapse

Question 1

Immunological synapse

Answer 1

The highly organised interaction between T cells and the activating or target cell it is in contact with. It is formed by TCR interacting with antigen on MHC and a second signal

Question 2

First signal

Answer 2

TCR and co receptor of T cell binding to antigen peptide on MHC

Question 3

Second signal

Answer 3

The signal needed to fully activate. It is between B7 on mature dendritic cells and CD28 on naïve T cells and CD40 on APCs and CD40L on effector CD4T cells

Question 4

Chemokine

Answer 4

Small chemoattractant protein that stimulates the migration and activation of cells particularly phagocytic cells and lymphocytes