3.3. Protein Kinases & Phosphatases

Question 1

Enzymes

Answer 1

1. Proteins
2. Highly specialized catalysts that accelerate the rate of a reaction
3. Enhance the specificity of metabolic chemical reaction
   (E.g. kinase)

Question 2

Kinases

Answer 2

1. Enzymes which modify 30% of human proteins
2. Phosphorylation of proteins
   - > add gamma phosphate from adenosine triphosphate (ATP) to amino acid with OH group

Question 3

Sequence motif

Answer 3

1. Primary amino acid sequence either side of the target serine threonine or tyrosine amino acid

Question 4

CDK

Answer 4

1. Cyclin dependent kinase

2. Requires cyclin binding

Question 5

PKA

Answer 5

Protein kinase A

Question 6

cAMP

Answer 6

Cyclic AMP

Question 7

PP2A

Answer 7

Regulates cell proliferation by reversing protein phosphoregulation in signaling pathways activated by growth factors

Question 8

PP2B

Answer 8

1. Calcineurin

2. It’s regulatory subunit bonds ca2+