Peptic Ulcer Disease Flashcards
wall of the GI tract (layers)
serosa
submucosa
mucosa
muscularis
parietal cells secretes
HCL acid
chief cells secretes
pepsinogen –. conver to pepsin
___ stimulates histamine secretion
gastrin
____ pepsine secretion
acetylecholine
3 segments of small intestine
duodenum, jejunum, ileum
The lamina propia (connective tissue that lines the mucosa of the villus) contains
lymphocytes
macrophages
plasma cells
What is the one way the gastric mucosa protected from the digestive actions of acid and pepsin?
Stimulation of mucus and bicarbonate by prostaglandins and nitric oxide
intestinal crypt contains
Stem cells,
secretory cells
Paneth epithelial cells
pathophysiology of gastritis
H. pylori
Autoimmune
Barret’s Esophagus pathophysiology
Reflux-damaged esophagus is repaired through a columnar metaplasia in which gastric and intestinal- type columnar cells replace squamous cells
Barrett’s metaplasia results from the proximal migration of stem cells from
Gastric cardia
Expansion of residual embryonic-type cells located at the gastroesophageal junction
Transitional basal cells located at the squamo-columnar junction.
3 pathogenic processes of H pylori
colonization,
immune escape
disease induction
H2 Receptor Antagonist examples
MOA
Suppresses acid secretion by blocking H2 receptors on parietal cells
Cimetidine
Famotidine
Nizatidine
common side effects of H2 receptor antagonist
Headache
- Drowsiness
- Fatigue
- Abdominal pain
- Constipation
- Diarrhea
- Antiandrogenic effects - CNS effects
- Pneumonia
PPI (- prazole) MOA
Suppress acid secretion by inhibiting H+ -K+ - ATPase
PPI side effects
Pneumonia
- Fractures
- Rebound acid
hypersecretion
- Hypomagnesemia - Diarrhea
Complications of PUD
bleeding
perforation
obstruction
