Pentose Phosphate Pathway

Question 1

What cells undergo the Pentose Phosphate Pathway

Answer 1

Biosynthetically active tissue cells

• primarily liver, adipose cells, mammary glands and erythrocytes
• no ATP is directly used

Question 2

Irreversible enzymes/reactions of PPP

Answer 2

-Glucose 6-P Dehydrogenase

Glucose 6-P -> 6-P Gluconolactone

• 6-P Gluconate Dehydrogenase

6-P Gluconate -> Ribulose 5-P

• Both produce NADPH*

Question 3

Net products of PPP

Answer 3

Ribulose 5-P

2 NADPH

2H+

CO2

Question 4

Committed, rate-limiting step of The PPP

Answer 4

G 6-P DHase oxidizing glucose 6-phosphate to 6-P gluconolactone

• 1st step of PPP

Question 5

Reversible steps of PPP

Answer 5

Carbon-shuffling steps

Question 6

Oxidative reactions of PPP

Answer 6

G6P is converted to 6-P Glucolactone -> 6-P Gluconate -> Ribose 5-P

• Only done is NADPH is required, produces 2 NADPH*

Question 7

Ribulose 5P can carbon switch into what molecules

Answer 7

F6P and GA-3P

Conducts glycolysis