Lipogenesis And Lipolysis

Question 1

Where is lipolysis and lipogenesis occurring?

Answer 1

Liver and intestinal epithelial cells

Question 2

Chylomicrons

Answer 2

Used by intestinal epithelial cells to transport triglycerides through blood stream

Question 3

VLDL’s

Answer 3

Used by liver cells to transport triglycerides out into the blood stream.

Question 4

How are adipose triglycerides released?

Answer 4

Mobilized/cleaved and enter directly into blood stream

Question 5

Acyl-CoA synthase

Answer 5

Activates fatty acids by use of ATP and CoA group

Question 6

Glycerol 3-P dehydra

Answer 6

Uses DHAP to form G3P via oxidation of NADH

Question 7

Glycerol kinase

Answer 7

Uses glycerol to generate G3P via ATP use

Question 8

Acyl-transferase

Answer 8

Conducts 1st and 3rd steps of lipogenesis

• uses acyl-CoA to generate ester bonds between fatty acids and glycerol.
• end products are phosphatidic acid and triglyceride respectively.

Question 9

Phosphohydrolase

Answer 9

Conducts 2nd step of lipogenesis

Removes phosphate group off 3rd carbon on phosphatidic acid’s glycerol backbone

• forms 1,2 diglycerol

Question 10

Triglyceride lipase (hormone sensitive lipase)

Answer 10

Regulatory enzyme that conducts 1st step in lipolysis.

• hydrolysis ester bond on C1 of glycerol backbone releasing 1 fatty acid

Question 11

Diglyceride lipase

Answer 11

Conducts 2nd step in lipolysis.

Hydrolyzes an ester bond on C2 to release 1 fatty acid

Question 12

Monoglyceride lipase

Answer 12

Conducts 3rd step of lipolysis

• hydrolysis ester bond on C1 to release one more fatty acid and glycerol