Penicillinase Flashcards

1
Q

Extended spectrum Pens 5 including combinations

A
  1. Carbenicillin indanyl
  2. Piperacillin
  3. Ticarcillin
  4. Pip + Tazobactam
  5. Ticarcillin + Clavulanate
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2
Q

PPSA drugs

3

A
  • Nafcillin
  • Oxacillin
  • Dicloxacillin
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3
Q

Penicillin G

Stability in acid?

Hydrolyzed by?

Spectrum?

Oral vs. IV dose?

Elimination where?

Coadmin with what does what?

A
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4
Q

Forms of Pen G

What is the preferred formulation?

What form is a repository?

What form is inactivated?

A
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5
Q

Pen G repository forms two kinds

What route only?

What are the uses for each?

A
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6
Q

Natural Penicillins

Oral one that is considered more stable?

What Spectrum does this have?

Resistance?

A
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7
Q

B-lactamase resistant penicillins?

2 of them

What are the 4 points about Isoxazolyls? What type of compound? No activity against?

These are the drug of choice for?

Indication is only for?

A
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8
Q

B-lactamase Resistant Pens

What prevents attack of penicillinase?

Methicillin

What are less tolerant to seric hinderance then PBPs?

Oral Stability?

Resistance? And why?

SEs?

A
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9
Q

Nafcillin

Resitant to?

Spectrum?

Can be taken in what form? What is recommended

Special toxicities? 4

Not be used in?

A
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10
Q

Isoxazolyl Penicillins Oral agents

4

Replacement of Phenyl with?

Stable to? Primarily used against ____ producing what?

Stability in?

Adequate? Also available in?

Inferior?

Most active compound?

Which one can act as a B-lactamase inhibitor?

Not active against?

Special toxicities with the drugs?

A
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11
Q

Aminopenicillins 2 of them

Spectrum?

Stable in? What forms?

Not stable to?

A
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12
Q

Ampicillin and Amox structures

A
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13
Q

Aminopenicillins

What isomer is more active?

What type of compounds?

better action against? Why is this?

What provides acid stability?

Not stable to?

A
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14
Q

Aminopencillins

Spectrum?

Gram (+) -

Gram (-)

What are they not affective against?

A
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15
Q

Amox uses? What combo has been approved for H. Pylori?

Ampicillin?

A
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16
Q

Amox vs Amp

Available form?

Gi absorb?

Dosing frequency?

Effect of food?

Activity against Pen resistant staph?

Salmonella activity?

Activity against shigella?

SEs?

17
Q

Combo Pen and B-lactamase inhibitors?

B-Lactam inhibitors block the breakdown of aminopenicillins by?

B-lact inhibitors are only?

What are the 3 in clinical use?

18
Q

Mechanism of B-lactamase inhibition

19
Q

Avibactam

Novel

Inhibitor of serine B-lactamase in what way?

20
Q

New generation of B-lactamase inhibitors

2

Spectrum?

21
Q

Amox + Clav

Clav is known as?

What does the spectrum now include?

22
Q

Amp and Sul

What type of inhibitor?

What enhances reactivity?

only use for what form

23
Q

Extended Spectrum Pens

Antipseudomonal Acidic Pens 3

Contain?

Spectrum?

Susceptible to?

24
Q

Extended Spectrum Pens

Carbenicillin Disodium

First pen with activity against?

What makes the compound hydrophillic?

Oral availability?

Decarb in?

25
Carb Disodium Spectrum? Uses? Combo? Not to be given with? SEs?
Cannot be coadministered with AGs must wait
26
Carbenicillin Indanyl Sodium Prodrug of? Stable in? Oral absorption What happens with high doses? Cant treat? What reduces the risk of Electrolyte abnormalities? Useful for?
27
Ticarcillin Bioisostere of? Not stable in? usually what form? half life? Ticar + Clav? uses?
28
Piperacillin Derivative of? What makes it hydrophillic? Longer c6? Not active against? Important for serious Gram (\_) infections Uses? oral? Stability?
29
Pip + Tazo Spectrum? Uses?
30
SAR of Pens 3 points
31
Comparison of Pens 16 Acid stability Stable to B lactamase Spectrum With food? Special Toxicities?