Penicillinase Flashcards
Extended spectrum Pens 5 including combinations
- Carbenicillin indanyl
- Piperacillin
- Ticarcillin
- Pip + Tazobactam
- Ticarcillin + Clavulanate
PPSA drugs
3
- Nafcillin
- Oxacillin
- Dicloxacillin
Penicillin G
Stability in acid?
Hydrolyzed by?
Spectrum?
Oral vs. IV dose?
Elimination where?
Coadmin with what does what?
Forms of Pen G
What is the preferred formulation?
What form is a repository?
What form is inactivated?
Pen G repository forms two kinds
What route only?
What are the uses for each?
Natural Penicillins
Oral one that is considered more stable?
What Spectrum does this have?
Resistance?
B-lactamase resistant penicillins?
2 of them
What are the 4 points about Isoxazolyls? What type of compound? No activity against?
These are the drug of choice for?
Indication is only for?
B-lactamase Resistant Pens
What prevents attack of penicillinase?
Methicillin
What are less tolerant to seric hinderance then PBPs?
Oral Stability?
Resistance? And why?
SEs?
Nafcillin
Resitant to?
Spectrum?
Can be taken in what form? What is recommended
Special toxicities? 4
Not be used in?
Isoxazolyl Penicillins Oral agents
4
Replacement of Phenyl with?
Stable to? Primarily used against ____ producing what?
Stability in?
Adequate? Also available in?
Inferior?
Most active compound?
Which one can act as a B-lactamase inhibitor?
Not active against?
Special toxicities with the drugs?
Aminopenicillins 2 of them
Spectrum?
Stable in? What forms?
Not stable to?
Ampicillin and Amox structures
Aminopenicillins
What isomer is more active?
What type of compounds?
better action against? Why is this?
What provides acid stability?
Not stable to?
Aminopencillins
Spectrum?
Gram (+) -
Gram (-)
What are they not affective against?
Amox uses? What combo has been approved for H. Pylori?
Ampicillin?
Amox vs Amp
Available form?
Gi absorb?
Dosing frequency?
Effect of food?
Activity against Pen resistant staph?
Salmonella activity?
Activity against shigella?
SEs?
Combo Pen and B-lactamase inhibitors?
B-Lactam inhibitors block the breakdown of aminopenicillins by?
B-lact inhibitors are only?
What are the 3 in clinical use?
Mechanism of B-lactamase inhibition
Avibactam
Novel
Inhibitor of serine B-lactamase in what way?
New generation of B-lactamase inhibitors
2
Spectrum?
Amox + Clav
Clav is known as?
What does the spectrum now include?
Amp and Sul
What type of inhibitor?
What enhances reactivity?
only use for what form
Extended Spectrum Pens
Antipseudomonal Acidic Pens 3
Contain?
Spectrum?
Susceptible to?
Extended Spectrum Pens
Carbenicillin Disodium
First pen with activity against?
What makes the compound hydrophillic?
Oral availability?
Decarb in?
Carb Disodium
Spectrum?
Uses?
Combo? Not to be given with?
SEs?
Cannot be coadministered with AGs must wait
Carbenicillin Indanyl Sodium
Prodrug of?
Stable in?
Oral absorption
What happens with high doses?
Cant treat?
What reduces the risk of Electrolyte abnormalities?
Useful for?
Ticarcillin
Bioisostere of?
Not stable in? usually what form?
half life?
Ticar + Clav?
uses?
Piperacillin
Derivative of?
What makes it hydrophillic?
Longer c6?
Not active against?
Important for serious Gram (_) infections
Uses?
oral? Stability?
Pip + Tazo
Spectrum?
Uses?
SAR of Pens
3 points
Comparison of Pens
16
Acid stability
Stable to B lactamase
Spectrum
With food?
Special Toxicities?
