Calcium Modulation

Question 1

Bone and Calcium

Two components of bone

What two cell types control bone formatIon? What are these cell types involved in?

Answer 1

1. Hydroxyapatite
2. Fibrous protein mainly collagen

Question 2

Hormonal Regulations of Serum Calcium Levels

What are the 3 hormones

Answer 2

Question 3

Calcitonin where is it synthesized?

What is required for activity?

Answer 3

Question 4

Calcitonin is secreted in response to?

CT ____ serum Ca2+ by 3 things:

Answer 4

Question 5

Parathyroid Hormone

Synthesis where?

Where does activity reside?

Answer 5

Question 6

PTH is secreted in response to ____ serum Ca2+

PTH ____ serum Ca2+ by: 4 things

Answer 6

Question 7

Vit D

In the liver what is cholesterol modified to?

Answer 7

Question 8

Bioactivation of Vit D

What 2 oxidative steps does D3 undergo?

What is the storage form of Vit D?

What are the differences of that and D3

Answer 8

Question 9

Bioactivation of Vit D

Second oxidation in response to?

What is the active form of Vit D?

Answer 9

Question 10

Bioactivation rxns

Answer 10

Question 11

Vit D

____ works in concert with PTH to do what 3 things?

Answer 11

Question 12

What does high serum Ca2+ activate?

Answer 12

Question 13

Vit D Biosynth and Inactivation Chart

Answer 13

Question 14

Summary of Serum Ca2+ Hormonal Control

Calcitonin ____ Serum Ca2+ in 3 ways

PTH ____ serum Ca2+ in 4 ways

Vit D ____ serum Ca2+ in 3 ways

Answer 14

Question 15

Calcium homeostasis related disorders

Disorders leading to?

or ____?

And disorders of?

Answer 15

Question 16

Reasons for having hypocalcemia

Answer 16

Question 17

hypercalcemia examples

Answer 17

Question 18

Bone remodeling examples

Answer 18

Question 19

Hypocal tx: 2 things

Hyper Tx: 7 things

Remodeling Tx: 7

Answer 19

Question 20

Drugs for Tx calcium homeostasis related disorders

6 agents

Answer 20

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