Peds & CF Flashcards
what is the first line option for acute otitis media?
high dose amoxicillin
80-90 mg/kg/day divided q12h for 5-10 days
what is the 2nd line option for acute otitis media?
amoxicillin/clavulanate 600mg/42.9 mg/5 mL strength
What are third line options for acute otitis media?
cefpodoxime, cefdinir
What medications are preferred for patients with ear tubes?
ofloxacin, ciprofloxacin drops
What medications are indicated for UTIs in pediatrics?
cephalexin, amoxicillin (resistance), amoxicillin/clavulanate, smx/tmp
What medications are preferred for complicated utis/last line?
fluoroquinolones
What is the treatment for RSV?
supportive therapy!
oxygen, fluids, mechanical ventilation, ECMO
What are prevention measures for RSV?
-flu vaccine
-RSV vaccine! nirsevimab (beyfortus)
abrysvo RSV vaccination while pregnant (32-36 weeks of gestation)
What is the original CFTR protein potentiator and what mutations does it cover & what age is it approved for?
kalydeco (ivacaftor) - type III & IV mutations (G551D)
1+ month
What are the monitoring parameters for ivacaftor?
LFTS x 3 months
yearly eye exam
take with fatty foods
What is the first combination CFTR protein potentiator & what age does it cover & what AE is of concern?
Orkambi (lumacaftor/ivacaftor)
1 + years
chest tightness and SOB
What is the first CFTR protein potentiator for F508del homozygous patients & what age?
Symdeko (ivacaftor/tezacaftor)
6+ years
What is the first CFTR protein potentiator for F508del patients who only need 1 mutation & age?
trikafta (elexacaftor/tezacaftor/ivacaftor)
2+ years
What is the CFTP potentiator that has once daily dosing and is non-inferior to trikafta?
Alyftrek (vanzacaftor/tezacaftor/deutivacaftor)
6+ years
What are the maintenance lung treatments in CF?
dornase alfa, hypertonic saline/mannitol
What anti-inflammatory medications are used in CF?
azithromycin, ibuprofen
What type of antibiotic coverage is needed in a CF exacerbations?
1 antibiotic for MRSA/MSSA coverage
2 antibiotics for pesudomonal coverage
MRSA: smx/tmp, doxycycline, vancomycin, linezolid, clindamycin
Pseudomonas: cefepime +tobramycin/amikacin, ceftazadime, piperacillin/tazobactam, levofloxacin, imipenem + cilastin, meropenem
What medications are indicated for pseudomonas colonization and not active infection?
tobramycin inh solution BID x 28 days
alternative: aztreonam 75 mg inh TID x 28 days
recurring pseudomonas: 28 days on, 28 days off, repeat cycle
What medication is needed for pancreatic insufficiency?
pancreatic enzymes!
Creon, zenpep, pancreaze
500-2500 units/kg/meal
MAX: 10000 units/kg/meal
