Gram Positive Agents

Question 1

What are target organisms for Vancomycin?

Answer 1

PRSP, MRSA, C.Difficile

Question 2

What are some major drug interactions with synercid?

Answer 2

statins, cyclosporine, tacrolimus, carbamazepine

Question 3

What are the adverse effects associated with synercid?

Answer 3

venous irritation, gastrointestinal, myalgias, arthralgias, rash

Question 4

What are adverse effects associated with Linezolid?

Answer 4

thrombocytopenia, anemia, peripheral and optic neuropathy

Question 5

does linezolid/tedizolid require dosage adjustments in the prescence of renal insufficiency?

Answer 5

no

Question 6

does daptomycin require dosage adjustments in the presence of renal insufficiency?

Answer 6

yes

Question 7

What are target organisms for daptomycin?

Answer 7

staphylococcus aureus bacteremia and endocarditis, VRE/MRSA
-do not use for treatment of pneumonia!

Question 8

What adverse effects are associated with daptomycin?

Answer 8

myopathy and CPK elevation, acute eosinophilic pneumonia

Question 9

Is dosage adjustments necessary in the precense of renal insufficiency with telavancin, oritavancin or dalbavancin?

Answer 9

yes with telavancin, dalbavancin
no with oritavancin

Question 10

are there any interactions of note with telavancin, oritavancin, dalbavancin?

Answer 10

they interfere with coagulation tests (PT, INR, PTT)

Question 11

What adverse affects are associated with telavancin, oritavancin, dalbavancin?

Answer 11

QTc prolongation - Telavancin
taste disturbances
nephrotoxicity
pregnancy category C