Pediatrics - Pyloric Stenosis & Neonatal Apnea Flashcards
What is the incidence of apnea of prematurity when the child is less than 30 weeks gestation?
80%
What are some contributing factors to apnea of prematurity?
CNS disease, Systemic illness, thermal/metabolic disturbances, airway anomalies
What are the 3 patterns of apnea?
Central: no airflow at nares and no muscular activity
Obstructive: muscular effort without nasal airflow
Mixed
How is ventilation regulated?
Central rhythm (pattern) generator--root cause Central chemoreceptors (CO2) Peripheral chemoreceptors (O2)
What are some possible causes of a less pronounced (flatter) CO2 response curve?
Prematurity
Flatter at 2 days than at 4 weeks postnatal age
Flatter in preterms with apnea than those without
Flatter during hypoxia
What is the premature infants ventilatory response to hypoxia?
Initial increase followed by a sustained decrease
At what age does the sustained increase ventilatory response mature?
At 1 week in term infants and about 3 weeks in preterm infants
What enhances the initial increase in ventilation?
CO2
What effects do halogenated anesthetics have on FRC and muscle tone?
Reduced FRC
Decreased muscle tone of airway, chest wall and diaphragm
What effect do halogenated anesthetics have on the CO2 response curve?
Dose-dependent decrease in slope and right shift of CO2 response curve
What effect do halogenated anesthetics have on the ventilatory response to hypoxia?
Depress ventilatory response to hypoxia (even at sub anesthetic doses)
What is the post conceptual age?
Age since birth - weeks premature
What type of pharmacological prophylaxis could potentially be used to help with AOP?
Caffeine (not routinely used, but helpfun)
What are the recommendations for elective surgery for patients with AOP?
Delay elective surgery beyond 46 weeks post conceptual age
At what age should infants be hospitalized and monitored with AOP?
<52 weeks PCA