Pediatric Prescribing Flashcards
Q: Why should intramuscular (IM) administration be avoided in children?
A: Children have less muscle, leading to variable absorption, and it is painful.
Q: Why is paracetamol metabolized differently in neonates?
A: Neonates have a slower metabolic process, leading to a prolonged drug half-life.
Q: Which drug should be avoided in children due to its association with Reye’s syndrome?
A: Aspirin.
Q: Why is drug clearance slower in neonates?
A: Immature enzyme systems and underdeveloped renal function, such as GFR.
Q: Name a drug that requires monitoring due to variable clearance in children.
A: Phenytoin.
Q: Why do neonates require higher doses/kg for water-soluble drugs?
A: Neonates have a higher body water content (80% vs. 60% in adults).
Q: What is the risk associated with low plasma protein concentrations in neonates?
A: Increased free drug levels, leading to higher toxicity risk.
Q: What should always be included when writing prescriptions for children?
A: Age in years/months, weight, and specific dosage in mg or micrograms.
Q: What does “off-label” use mean?
A: Using a licensed medication outside the terms of its marketing authorization (e.g., for a different dose or age group).
Q: Why is ibuprofen contraindicated for children with chickenpox?
A: It can increase the risk of serious skin infections.
