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Biochemistry Disease States > PDH > Flashcards

PDH Flashcards

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1
Q

Beriberi

A

Thiamine deficiency (malnourishment, alcoholism)

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2
Q

Thiamine deficiency

A

malnutrition (asi alcoholism). PDH and a-KGDH (CAC) disruption Bc TPP is cofactor in PDH, a-Kgdh, and Transketolase rxn of nonox PPP. neuro and cardio disorders. lactic acidosis.

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3
Q

Arsenite poisoning

A

bind to SH groups. disrupt E2 lipolyllysine swinging group in PDH and a-KGDH (CAC)

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4
Q

Mercury poisoning

A

bind to SH groups. disrupt E2 lipolyllysine swinging group in PDH and a-KGDH (CAC)

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5
Q

Leigh’s

A

SNE. subacute necrotizing encephalopathy. PDH def. rapid progressive CNS degeneration. symptoms similar to beriberi: opthalmaloplegia, ataxia, lactic acidemia, seizures, dying brain cells

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Biochemistry Disease States (33 decks)

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