Extracellular Matrix (ECM)

Question 1

Osteoarthritis (OA)

Answer 1

aggrecan degredation. aggrecan is a proteoglycan that maintains high GAG–>lubricates

Question 2

Multiple Sclerosis

Answer 2

demyelinating. autoimmune myelin sheath removal.
excessive WBC migration, chronic inflammation

Natalizumab. binds integrin, decrease extravasation (migration) and reduce inflammation

Question 3

Epidermolysis Bullosa

Answer 3

keratin mutation