Membranes

Question 1

Gas Gangrene

Answer 1

C. perfringens secretes lipase that digests, hydrolyzes phosphocholine. Breaks down membrane in endothelial cells of blood vessels

Question 2

Type 2 Diabetes

Answer 2

Hyperglycemia.

Sulfonylurea: stimulate insulin. block ATP K+ channel–>depolarization. Ca+ enters, insulin secreted

Thiazolidinediones: increase glyceroneogen (by inducing PEPCK), reducing fFAs in blood. GAIN INSULIN SENSITIVITY

Question 3

PHHI: Persistent Hyperinsulinemic Hypoglycemia of Infancy

Answer 3

Hyperglycemia.

Treatment: Diazoxide: decrease insulin. no depolarization. insulin not secreted.
(diazoxide also a hypertension treatment)

Question 4

Gastroesophageal Reflux

Answer 4

Cl-/bicarb antiport exchanger malfunct

Treatment: Omeprazole (Prilosec). block gastric acid secretion

Question 5

Type 1 Diabetes

Answer 5

insulin dependent. absolutely no insulin produced. prone to diabetic ketoacidosois (glucose not taken up, prompting b-oxidation of fFA–>KBs). hyperglycemic.