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Biochemistry Disease States > Microtubules > Flashcards

Microtubules Flashcards

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1
Q

Taxol

A

anti-cancer drug, breast and ovarian cancer. binds to tubilin and stabilizes microtubules. inhibits mitosis by preventing depolymerization when pulling sister chromatids apart during Anaphase

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2
Q

Colchicine

A

Gout treatment. drug prevents polymerization, reducing WBC migration and inflammation

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3
Q

Nocodazole

A

prevents spindle assembly during mitosis. arrests cells in G2–used in lab

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4
Q

Vinblastine and Podophyllotixin

A

microtubule stabilizing drug. cancer drug

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5
Q

Alzheimer’s

A

extracellular amyloid plaques. intracellular neurofibrillary tangles. Tau protein stabilizes microtubules. Tau hyperphosphorylated, aggregates into neurofibrillary tangles

research drugs block Tau phosphorylation

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Biochemistry Disease States (33 decks)

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