Microtubules Flashcards
1
Q
Taxol
A
anti-cancer drug, breast and ovarian cancer. binds to tubilin and stabilizes microtubules. inhibits mitosis by preventing depolymerization when pulling sister chromatids apart during Anaphase
2
Q
Colchicine
A
Gout treatment. drug prevents polymerization, reducing WBC migration and inflammation
3
Q
Nocodazole
A
prevents spindle assembly during mitosis. arrests cells in G2–used in lab
4
Q
Vinblastine and Podophyllotixin
A
microtubule stabilizing drug. cancer drug
5
Q
Alzheimer’s
A
extracellular amyloid plaques. intracellular neurofibrillary tangles. Tau protein stabilizes microtubules. Tau hyperphosphorylated, aggregates into neurofibrillary tangles
research drugs block Tau phosphorylation
