PCOL of Psychostimulant misuse Flashcards

1
Q

psychostimulants activate the ___ resulting in alertness, excitation, and elevated mood

A

CNS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

role of mesolimbic dopamine system

  • prefrontal cortex - planning, judgement
  • ___ - reward
  • amygdala - emotion, fear
  • hippocampus - memory and learning
  • ventral tegmental area
A
  • nucleus accumbens
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

nicotine - MOA

  • at least ___ different subunits
  • nicotine activates nicotinic acetylcholinergic receptors
  • ___ enters cell, ___ exits the cell = action potential
  • heterogeneity of subunits determines how many ___ of ACh bind to receptor
  • variation in receptor composition at different sites may influence physiological response
A
  • 12
  • Na, K
  • molecules
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

acetylcholine vs nicotine

  • similarities between nicotine and ACh are charged ___ groups and hydrogen bond acceptor groups
  • nicotine is membrane ___ at physiological pH (weak base)
  • nicotine is not degraded by ___
A
  • amino
  • penetrable
  • AChe
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q
A

Suggests that pharmacology of the drug isn’t a main contributor of addiction, its about the factors surrounding the use

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

partial agonist therapy

  • causes release of ___
  • ___ addicitive
  • nicotine replacement therapy relatively ineffective alone
  • ___ partial agonist increases quit rate success
A
  • dopamine
  • highly
  • varenicline
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

T or F: cocaine acts differently due to its size

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

why is pseudoephedrine kept behind the counter?

if you ___ the OH in pseudoephedrine to an H, you get meth

cant do this to phenylephrine

A

reduce

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what drug is amphetamine linked with chloroethyl-theophylline?

A

fenethylline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

MOA of cocaine

antagonists of amine transporters
___ ≥ ___ > ___
- prevents ___ reuptake
- increase concentration and duration of action of __

A

DAT, SERT, NERT
DA, DA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

MOA of methamphetamine ecstasy and bath salts

amphetamines, ecstasy, and bath salts all compete for ___
- resemble endogenous DA, NE
- block ___ reuptake
- push out ___ from vesicles)
- increase extra-vesicular DA
- ___ transport (gradient)
- amphetamines are ___

activate trace amine-associated receptor (TAAR1)
- phosphorylates DAT
- induces ___ transport function

A
  • reuptake
  • DA
  • DA
  • reverse
  • MAOis
  • reverse
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

sythetic cathinones are derivatives from the ___ plant
- mild euphoria, excitment
- similar to strong coffee

A

Khat

man chewing on tennis ball

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

common synthetic cathinones

  • produced in china and south east asian counties
  • designer drugs

common names
- bath salts
- plant food
- molly
- flakka
- scarface

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

clinical effect of methamphetamine abuse

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q
  • DA downregulation is not evidence of a broken brain
  • receptor downregulation believed to mediate ___ symptoms
  • recovery of DA receptors shows ability to return to ___
A
  • withdrawal
  • homeostasis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

T or F: stimulants enhance cognitive ability

A

FALSE

17
Q

sympathomimetic toxidrome

MATHS

mangement
1) treat agitation, HTN, and seizures with ___
2) avoid pure ___ due to unapposed alpha agonism

  • HTN normally responds to sedation
  • hy[erthermia denotes a poor prognosis
  • aggression and paranoia often seen
A
  • Mydriasis
  • Agitation, arrhythmia, angina
  • Tachycardia
  • HTN, hypertermia
  • Seizure, sweating

1) BZDs
2) BBs