Marijuana Flashcards
origin, components, and use
cannabis sativa/indica
- > 400 compounds
- ___ effects (?)
- THS, cannabidiol, cannabinol
marijuana
- dried leaves and flowers
hashish
- compressed stalked resin glands (trichomes) from cannabis flower blossoms
inhalation and ingestion
- entourage
Hemp vs Marijuana
Hemp
- contains < ___ % of THC
- grown for agricultural products such as textiles, seeds, and oils
marijuanan
- contains ___ - ___ % of THC
- 0.3%
- 15-20%
T or F: cannabis remains schedule I under federal controlled substance act
TRUE
what is this?
delta 9 THC
what is this?
delta 8 THC
synthetic marijuana use is widespread, though illegal
- agents are more potetn than ___
“spice”
THC
acute cannabis intoxication
perceptual
- temporal ___
- auditory, visual, tactile illusion
- de- ___
physical
- ___ cardia
- postural ___
- conjunctival injection
- dry mouth
- increase appetite
affective
- euphoria
- disinhibition
- anxiety
- emotional lability
cognitive
- suspiciousness or ___ ideation
- impaired judgement
- impaired reaction time
- impaired attention
- slowing
- de-personalization
- tachycardia
- paranoid
endocannabinoid system (ECS)
widely distributed in CNS
- ___ : (CB1, CB2)
- ___ : (anandamide and 2-AG)
- ___ : (EMT, endocannabinoid membrane transporter)
- ___ : (fatty acid amide hydrolase, FAAH; mono-glycerol lipase, MAGL; diacyl glycerol lipase DAG)
- receptors
- ligands
- transporter
- enzymes
endocannabinoids and phytocannabinoids serve as ___ regulators of neurotransmission, inhibiting release of ___ and ___
- THC is a ___ agonist as CB1R while synthetic cannabinoids are ___ agonist
- retrograde
- GABA
- glutamine
- partial, full
CB __ expression in brain is higher than CB __ receptor expression
Brain: CB __»_space; CB __
- ___ levels in respiratory centers of brainstem
- decreased respiration, depression, coma
1, 2
1, 2
low
CB __ expression in perphery is higher than CB __ receptor expression
periphery: CB __»_space; CB __
CB2 - lymphocytes
- possible way to modulate inflammation
CB1 - liver
- increase ___
- upregulated in liver fibrosis
2, 1
2, 1
lipogenesis
FDA approved cannabinoid drugs
marinol (dronabinol)
- synthetic ___ in sesame oil
- schedule III
- counter loss ___
- tachycardia, red eyes
nabilone (Cesamet)
- THC mimetic
- schedule II
- anti ___
- chronic pain (off label) - fibromyalgia, MS
- delta 9 THC
- appetite
- emetic
CBD PCOL and Use
- low affinity for CB receptor
- may antagonize THC at CB __
- ___ effects on ECS
- Lacks ___ effects
CBD oil with < ___ THC is legal in IN
- FDA approved for ___ disorder
- most commonly used for pain even though no evidence
- CB1
- promiscuous
- euphoric
- 0.3%
- seizure
T or F: CBD products are unregulated and of unknown and variable quality
True
CBD is approved for rare seizure disorders ( ___ )
- Dravet Syndrome
- Lennox-Gastaut Syndrome
Epidiolex
cannabis use disorder
≥ ___ criteria
2
is cannabis use associated with mental health disorders
- extremely difficult to prove and controversial
- growing evidence for ___ with several disorders, cause and effect not established
risk factors and pathway to psychosis
- ___ of use onset and ___ appear to be key determinants
association
- age
- potency
canabinoid hyperemesis syndrome
diagnostic criteria
- cyclic ___ /abdominal pain
- presentation after prolonged, excessive use
- relief by sustained cessation may be association with pathological bathing ( ___ showers/baths)
treatment
- cannabis ___
- BZDs
- Haloperidol
- ___ cream (abdomen)
- vomiting
- hot
- cessation
- capsaicin
