5 ACS part II Flashcards

1
Q

initial recommendations

12 lead ECG
- within __ mins of arrival at an emergency facility
- if the initial ECG is not diagnostic but the patient remains symptomatic and there is a high clinical suspicion for ___ , serial ECGs should be performed every ___ - ___ min for the first hour

A
  • 10
  • ACS, 15-30
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2
Q

initial recommendations

serial troponin
- levels should be obtained at presentation and ___ - ___ hours after symptom onset
- ___ troponin is preferred
- repeating troponin levels will identify a rising and/or falling pattern

A

3-6
high sensitivity

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3
Q

UA/NSTEMI Treatment

MONA
Reperfusion
- early invasive strategy vs. ischemia guided strategy
- no ___

Antiplatelets
- DAPT = ___ and ___
- ___ month duration
- ___ or ___ preferred
- +/- GPIIb/IIIa inh (unlikely to use)

Anticoagulation
- LMWH or UFH

BB
ACEi or ARB
Statin
NTG prn

A
  • fibrinolytic
  • ASA, P2Y12
  • 12
  • ticagrelor, prasugrel
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4
Q

STEMI Treatment

MONA
Reperfusion
- ___ vs fibrinolytic

Antiplatelets
- DAPT = ___ + ___
- ___ month duration
- fibrinolytic: ___ preferred
- PCI: ___ or ___ preferred
- +/- GPIIb/IIIa inhibitior

Anticoagulation
- UFH or ___

BB
ACEi or ARB
Statin
NTG prn

A
  • PCI
  • ASA, P2Y12i
  • 12
  • clopidogrel
  • ticagrelor, prasugrel
  • bivalirudin
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5
Q

MONA

A

morphine
oxygen
NTG
ASA

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6
Q

early hospital care immediately upon arrival - MONA

morphine - to relieve chest pain

initial dose
- ___ - ___ mg IV
- followed by __ - __ mg IV q 5-15 min

SE
- seddation
- respiraotry depression
- N/V

Avoid NSAIDs during hospitalization (except ___ )
- NSAIDS lead to Na and water ___ = increase risk of ___

A
  • 4-8, 2-8
  • ASA
  • retention, MACE
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7
Q

early hospital care - immediately upon arrival - MONA

oxygen
maintain O2 sat of > ___ %

A

90%
(dont need to initiate if above 90%)

pateints have trouble breathing due to impending feeling of doom

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8
Q

early hospital care - immediately upon arrival

Nitroglycerin (NTG)
- ___ = increase blood flow to the heart

SL NTG: ___ - ___ mg q __ min x 3 for angina

IV NTG: for persistent ischemia, HF, or HTN
- start at ___ mcg/min
- titrate by ___ mcg/min q 5 min (MAX: ___ mcg/min)

SE
- headache
- hypotension

A

vasodilator
0.3-0.4, 5
10
5
200

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9
Q

T or F: transdermal NTG is preferredd in the setting of ACS

A

FALSE
- has to absorb, not rapid, 15-60 min onset

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10
Q

NTG CI

nitrates are contraindicated with the use of a ___
sildenafil: within ___ hrs
vardenadil: within ___ hrs
tadalafil: within ___ hrs

A

PDEi
24
24
48

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11
Q

early hospital care - immediately upon arrival

ASA
___ - ___ mg chewable for 1 dose
- give to ALL patients without contraindications to ASA

A

162-325

if EC is all that is availabe, have pt chew

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12
Q

T or F: if the patient takes 81 mg ASA and they already too their dose that morning, we would still give a loading dose of 325 mg

A

T
the pt still needs a loading dose, If they just to their dose, you could give 3 additional 81 mg tabs (for a total dose of 324 mg)

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13
Q

Steps with Time

within 10 min of arrival: ___
- repeat q 15-30 min for 1 hour if patient remains symptomatic

at presentation: ___
- repeat q 3-6 hours for first 12 hours

immediately upon arrival: ___

A

ECG
high sensitivty troponin
MONA

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14
Q

reperfusion strategies

procedures: ___ and ___
PCOL: ___ therapy

A

PCI, CABG
fibrinolytic

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15
Q

Coronary Angiography - “heart cath”

shows which arteries in the heart have blockages
1) catheter is inserted into ___ and ___ artery and fed up to the heart
2) ___ is injected into coronary arteries
3) an ___ picture is taken and shows the blocked arteries
4) a ___ is place if needed

A

radial, femoral
dye
X-ray
stent

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16
Q

Fibrinolytics “clot busters”

convert ___ into ___ (the enzyme that degrades fibrin)

A

plasminogen, plasmin

17
Q

Fibrinolytics

Tenecteplase (TNK-tPA)
just __ dose
Dosing:
- < 60 kg: ___ mg
- 60-69 kg: ___ mg
- 70-79 kg: ___ mg
- 80-89 kg: ___ mg
- 90 or > than 90 kg: ___ mg

A

1
30
35
40
45
50

18
Q

Fibrinolytics

Reteplase (rPA)
Dosing:
- ___ units for ___ doses
- ( ___ min apart)

A

10 x 2
30

19
Q

Fibrinolytics

Alteplase
(tPA)
- ___ mg bolus
- then ___ mg/kg over 30 mins (MAX: ___ mg)
- then ___ mg/kg (MAX: ___ mg) over 60 min
- max total dose: ___ mg

A
  • 15
  • 0.75, 50
  • 0.5, 35
  • 100
20
Q

Fibrinolytics

TNK-tPA, rPA, and tPA are ___
- no strong ___ for one agent over another

Streprokinase (SK)
- first fibrinolytic
- less ___
- less ___ for fibrin
- not often used in the US

A

expensive
- preference
- expensive
- specific

21
Q

absolute CI to Fibrinolytics

  • history of ___ hemorrhage
  • ischemic stroke within the past ___ months
  • presence of a cerebral vascular malformation of primary or metastatic intracranial ___
  • aortic ___
  • active ___
  • significant closed-head of facial trauma within the past ___ months
A
  • intracranial
  • 3
  • malignancy
  • dissection
  • bleeding
  • 3
22
Q

relative CI to Fibrinolytics

  • ischemic stroke > ___ months ago
  • severe/uncontrolled HTN (SBP > ___ mmHg or DBP > ___ mmHg)
  • dementia
  • any intracranial disese that is not an absolute CI
  • if cardiopulmonary resuscitation was administered for > ___ mins
  • major surgery within the last ___ weeks
  • internal bleeding within the last ___ - ___ weeks
  • vascular punctures not able to be compressed if they were to bleed
  • ___
  • current ___ therapy
  • previous allergic reaction to fibrinolytic drugs
A
  • 3
  • 180, 110
  • 10
  • 3
  • 2-4
  • pregnancy
  • warfarin
23
Q

Reperfusion Therapy: STEMI - PCI vs Fibrinolytic

reperfusion therapy should be administered to all eligible STEMI patients whose symptoms began in the past __ hours

PCI ___ fibrinolytic
- higher rates of infarct artery patency
- lower rates of recurrent ischemia, reinfarction, and emergency repeat revascularization procedures
- lower rates of intracranial hemorrhage
- lower rates of death

A

12
- (> > >)

24
Q

Reperfusion Therapy: STEMI

door-to-needle time = within ___ min of hospital arrival

door-to-balloon time: within ___ min of hospital arrival

A

30
90

25
Q

Reperfusion Therapy: STEMI

fibrinolytic is recommended for STEMI patietns at non-PCI-capable hospitals
- when patients are greater than ___ min away from PCI-capable hospital
- should be administered within ___ mins of hospital arrival

A

120
30

26
Q
A
27
Q

Reperfusion Therapy: NSTEMI/UA

early invasive vs. ischemia guided
- ___ are NOT recommended

early invasive = coronary ___ +/- revascularization
- preferred for patients with ___ risk features such as
- refractory ___
- new-onset ___
- rising ___
- new ST segment ___

Ischemia-Guided = “Medical” Management
- treatment with evidence-based madications
- no heart ___ (unless the patient has refractory or recurrent ischedmic symptmoms or becomes hemodynamically ___ )

A

fibrinolytics
angiography
- high
- angina
- HF
- troponin
- depression
- catheterization
- unstable