bipolar (watts)

Question 1

treatment of bipolar disorder

hospitalization
psychotherapy
pharmacotherapy
- mood stabilizers: ___ , anticonvulsants
- atypical antipsychotics
- ___ (verapamil, nimodipine)
- combo therapy ( + ___)

Answer 1

• lithium
• CCB
• BZD

Question 2

lithium (light) PCOL

MOA not clearly understood
- depletion of ___ and associated signaling (IP3 and PKC)
- modulate ___ (Phosphorylation and binding partners)

• small therapeutic index
• acute vs chronic
• lag time for effectiveness
• loading dose

Answer 2

PIP2
GSK3

PLC like man with vasectoy trying to have a baby

Question 3

anticonvulsants - valproic acid and sodium valproate

multiple MOA
- increase ___ tone (increase GAD activity, inhibit GABA transaminase)
- block ___ channel
- block T type ___ channels
- inhibit ___ deasetylase (HDAC5)

Answer 3

• GABAergic
• Na
• Ca
• histone

Question 4

anticonvulsants

___ (Tegretol) and ___ (Trileptal)
- ___ channels

___ (Lamictal)
- ___ and ___ channels

___ (Topamax)
- ___ channel (may enhance ___ at receptor and blocks ___ AA receptors

Answer 4

carbamazepine, oxcarbazepine
- Na

lamotrigine
- Na,Ca

topiramate
- Na, GABA, excitatory

Question 5

atypical antipsychotics

• ___ (Zyprexa)
• ___ and ___ (Symbyax)
• ___ (Seroquel)
• ___ (Risperidol)
• ___ (Geodone/Zeldox)
• ___ (Latuda)
• ___ (Abilify)

Answer 5

• olanzapine
• olanzapine, fluoxetine
• quetiapine
• risperidone
• ziprasidone
• lurasidone
• aripiprazole