PBC Flashcards
1
Q
What is aetiology PBC?
A
Autoimmune attack on small bile ducts- Canals of Hering
2
Q
What causes disease in PBB?
A
Inflammation causes obstruction in outflow of bile causing cholestasis
3
Q
What are symptoms of PBC?
A
Fibrosis and cirrhosis Itching Jaundice GI disturbance Xanthoma and Xanthelasma
4
Q
Who gets PBC?
A
Middle aged women
5
Q
Which autoab is seen in PBC?
A
AMA +ve
6
Q
What is prognosis of PBC?
A
Variable
Some lead to HCC or osteoporsis
7
Q
What is seen in LFTs in PBC?
A
ALP rises first AMA EST IgM Biospy
8
Q
What is management of PBC?
A
Ursodeoxycholic acid to reduce cholestrol absorption
CHOLESTYRAMINE- prevent bile acid absorption and reduced itching
Immunosupression
LIver transplant
9
Q
What is the trick for rememvering PBC?
A
The M rule:
IgM
anti-Mitochondrial antibodies, M2 subtype
Middle aged females
