LFTs

Question 1

Which LFTs represent hepatocytes?

Answer 1

Transaminases: AST and ALT

Question 2

Which LFTs represent cholestatic function?

Answer 2

ALP

GGT

Question 3

What is an indication of liver function?

Answer 3

Billi
ALb
PT time

Question 4

APPT

Answer 4

Increased in derangement
Extrinsic Pathway
Measure of liver damage severity

Question 5

Albumin

Answer 5

Measure of liver damage severity

Decreased in derangement

Question 6

GGT

Answer 6

Microsomal enzyme produced in liver

Indirect marker of cholestasis

Question 7

ALP

Answer 7

Cholestasis marker

ALP >3 fold rise and <10 fold rise in ALT in cholestasis

Question 8

ALT

Answer 8

Produced in the liver and negligibly in other organs
Marker of hepatocellular injury
>10 fold rise in this and <3 fold in ALP is hepatocellular

Question 9

AST

Answer 9

Produced a lot by other places and negligably by liver

Marker of hepatocellular damage

Question 10

What is up in Alcohol damage?

Answer 10

AST up more than ALT

Question 11

NAFL LFT?

Answer 11

ALT up more than AST

Question 12

GGT speficific or no?

Answer 12

Non specific

But if ALP is raised then GGT raised if cause liver, and not if cause is bony.