Paulson - Preconception Counseling, Infertility, Abortion, and Maternal-Fetal Physiology Flashcards
complications that increase morbidity/mortality to mother and/or fetus occur in __% of pregnancies
5-20
what does preconception counseling include
likelihood of pregnancy in ALL reproductive age women
desire to become pregnant AND when
contraception
quit smoking
healthy weight and diet
limit etoh
review meds
infectious dz
genetic screening options
partner violence
travel hx
ask about drug use
is marijuana safe in pregnancy
no
are varicella/rubella vaccines safe in pregnancy
no →
live vaccines are not safe
2 vaccines that are safe in pregnancy
pertussis
hep B
infertility is defined as no pregnancy after __ months of trying w. normal sexual activity w.o contraception
12
risk for infertility increases at what age
35 yo
what is ART
assisted reproductive technologies
3 types of ART
ovulation induction
insemination w. sperm
in vitro fertilization
3 types of infertility
female
male
unexplained
5 causes of female infertility
anovulation
endometriosis
fibroids
tubal factor
cervical factor
work up for male infertility should include (4)
hx
PE
semen analysis
chromosomal studies
what might you see on hx for male infertility (6)
sexual dysfxn
etoh/drug use
STDs
cryptochordism/orchiectomy/mumps
DM
neurologic dz
what might you find on PE for male w. infertility
varicocele
absence of vas deferens
systemic illness
semen analysis includes (3)
concentration
motility
morphology
female infertility work up includes (5)
hx/PE
ovulation monitoring
hormone analysis
hysterosalpingogram
chromosomal studies
cardiac changes associated w. pregnancy (4)
increased CO
lower BP
increased HR
increased venous pressure in LE
HR in pregnant women increases by ~__ over the course of pregnancy
15 beats/min
heme changes associated w. pregnancy (5)
50% increased plasma volume
20-30% RBC increase
WBC increase
decreased platelets
hypercoaguable state
GI changes associated w. pregnancy
n/v
GERD
constipation
delayed gallbladder emptying
endocrine changes associated w. pregnancy (2)
increased estrogen and thyroid activity
renal changes associated w. pregnancy
kidneys enlarge
GFR increases
pulmonary changes associated w. pregnancy
increased tidal volume and inspiratory capacity
derm changes associated w. pregnancy
spider angiomas and palmar erythema
hyperpigmentation: nipples, umbilicus, linea nigra, melasma/cholasma
__% of women experience first trimester bleeding
25
5 causes of first trimester bleeding
implantation into endometrium
abortion
ectopic pregnancy
molar gestation
infxn
termination of pregnancy before 20 weeks
abortion
2 types of abortion
spontaneous (SAB)
therapeutic (TAB)
sx of abortion (5)
bright red bleeding
low back pain
abd pain/cramps
cervical dilation
passage of conception products
lab/imaging findings associated w. abortion
bHCG levels falling/inadequately rising
US: empty gestational sac/lack of cardiac activity/growth
all products of conception expelled before 20 weeks
cervical os closed
complete abortion
management of complete abortion
obs for bleeding
monitor HCG
send conception products to path
pregnancy can not be saved
cervical os dilated
products of conception NOT passed
inevitable abortion
inevitable abortion has a __ prognosis,
and management includes (3)
poor
D&C, type and screen, Rh
possible pregnancy loss
no products of conception passed
cervical os closed
pregnancy can continue w.o further problems
threatened abortion
management of threatened abortion
pelvic rest
some products of conception passed
cervical os dilated
heavy bleeding
incomplete abortion
management options for incomplete abortion
D&C
medical or expectant management
embryo not viable prior to 20 weeks
products of conception retained in uterus
no cervical dilation
+/- bleeding
missed abortion
management of missed abortion
D&C
medical or expectant management
any embryonic or fetal demise w. uterine infxn
septic abortion
sx of septic abortion
uterine bleeding
fever
increased leukocytes
abd pain
cervical motion tenderness
foul smelling d.c
septic abortion is usually caused by
retained products of conception
ascending polymicrobial infxn
dx for septic abortion
CBC
UA
endocervical cultures/blood cultures
abd xray
US
xray for septic abortion rules out
uterine perforation
US for septic abortion rules out
retained products of conception (POC)
tx for septic abortion
admit + IV broad spectrum abx
+/- D&C if retained POC
work up for elective abortion must include
complete social and medical hx
PE
what does PE include for elective abortion
uterine size/position
3 meds used for elective abortion
mifepristone
misoprostol
methotrexate
which elective abortion med inhibits progesterone
mifepristone
which elective abortion med induces uterine contractions
misoprostol
which elective abortion med stops fast growing cells
methotrexate
methotrexate must be used in combo w.
misoprostol
surgical options for elective abortion
suction or surgical curretage
dilation and evacuation
which surgical option would you use for elective abortion in a second trimester pregnancy
dilation and evacuation
mc, safest, and most effective method for terminating pregnancy of 12 weeks or less
suction curretage
3 or more SABs before 20 weeks
recurrent pregnancy loss
5 possible causes for recurrent pregnancy loss
genetic
AI
anatomic
endocrine
thrombophilic
does recurrent pregnancy loss indicate low chance for successful pregnancy
no → ~60% have viable pregnancy
embryo fails to develop or is reabsorbed after loss of viability
same-same “blighted ovum”
anembryonic pregnancy
dx for anembryonic pregnancy
US showing empty gestational sac w.o fetal pole
sx of anembryonic pregnancy
mild pain/bleeding
cervix closed
retained non-viable pregnancy
sx of anembryonic pregnancy
mild pain/bleeding
cervix closed
retained non-viable pregnancy
2 gestational disorders
ectopic pregnancy
gestational trophoblastic dz/dz of trophoblastic tissue
gestational trophoblastic dz/dz of trophoblastic tissue includes (3)
hydatidiform mole
invasive mole
choriocarcinoma
hydatidiform mole can be (2)
complete
partial
implantation of the fetus in any site other than the endometrial cavity
ectopic pregnancy
mc site of ectopic pregnancy
fallopian tubes → 95%
rf for ectopic pregnancy (5)
prior ectopic
PID
smoking
anatomic abnormalities
IUD
3 complications of ectopic pregnancy
tubal rupture
hemorrhagic shock
death
leading cause of pregnancy related deaths in first trimester
ectopic pregnancy
what do you think when you see: adnexal mass, uterine changes, hemodynamic instability/vitals
ectopic pregnancy
nearly 100% of ectopic pregnancies are associated w.
pelvic or abd pain
other sx of ectopic pregnancy
amenorrhea
syncope
labs to order for ectopic pregnancy dx (3)
CBC
bHCG
type and screen/Rh
+/- progesterone
intrauterine pregnancy at beta HCG level of 1500-2000
transvaginal US findings associated w. ectopic pregnancy
what is the discriminatory zone
bHCG levels 1500-2000
the discriminatory zone for bhcg refers to
the point at which a gestational sac can be visualized
progesterone < __ suggests non viable pregnancy
5
first line pharm for ectopic pregnancy
methotrexate
what labs need to be monitored w. methotrexate
LFTs
Cr
close f.u up bHCG
what level should bHCG be after MTX tx
0
s.e of MTX
abd pain
bleeding
n/v
sx of tubal rupture and need for emergent care for pt on MTX
severe pain
dizziness
syncope
2 surgical options for ectopic pregnancy
salpingostomy
salpingectomy
group of rare pregnancy related tumors
gestational trophoblastic dz
sx of gestational trophoblastic dz
abnormal fertilization
absence of fetal heart tones/structures
HCG higher than expected for gestational age
rapid enlargement of uterus
what do you think when you see preeclampsia in first trimester or early second trimester
molar pregnancy
may be pathognomonic
benign neoplasm derived almost entirely from abnormal placental (trophoblastic) proliferation
hypatidiform mole → molar pregnancy
neoplasm contains no fetal tissue
diffuse trophoblastic proliferation
46xx or 46xy
BHCG > 50,000
complete molar pregnancy
neoplasm contains some fetal tissue
focal trophoblastic proliferation
69xxx OR 69xxy
BCHG < 50,000
partial molar pregnancy
molar pregnancy is mc in what pt populations
early teens
perimenopausal
molar pregnancy may precede
choriocarcinoma
dx for hypatidiform mole (molar pregnancy)
US
labs hypatidiform mole (molar pregnancy)
BHCG
snowstorm pattern
normal gestational sac/fetus not present
+/- theca lutein cysts
US findings for complete molar pregnancy
focal areas of trophoblastic changes
+/- fetal tissue
focal cystic changes in the placenta
partial molar pregnancy
hallmark US finding for partial molar pregnancy
focal cystic changes in placenta
multiple grapelike vesicles filling and distending the uterus
edema of villous stroma, avascular villi, nests of proliferating trophoblastic elements
histology findings from dilation and evacuation of molar pregnancy
tx for confirmed molar pregnancy
suction and curretage
pathologic evaluation of tissue
+/- prophylactic chemo
surveillance w. HCG labs
invasion and/or perforation of myometrium
locally destructive
+/- emboli to distant sites
persistent elevated HCG
invasive mole
complication of invasive mole
uterine rupture
malignant choriocarcinoma
malignant tumor, usually of the placenta
abnormal proliferation of cytotrophoblastic and syncytiotrophoblastic cells that produce BHCG
choriocarcinoma
choriocarcioma arises from:
50%:
50%:
pre-existing molar pregnancy
retained placental cells post abortion or placenta retention after normal pregnancy
choriocarcinoma is very sensitive to __
and has a __ prognosis
chemo
good
choriocarcinoma may be diagnosed in the setting of (4)
- rise in HCG of 10% or more for 3 or more values over 2 weeks
- plateau in 4 or more HCG values over 3 weeks
- HCG levels elevated at 6 mo post evacuation
- tissue dx