PATTH 5 Flashcards

1
Q

Érysipèle

A

Inflammation tissu cut/ ss cut

Infection bact -> streptooque

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2
Q

Tuberculose

A

Infection bact

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3
Q

Polyarthrite rhumatoide

A

Rhumatisme entrainen infla chronique

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4
Q

3 phase inflammation

A

Initiation -> effecteur Ir + sys coag + sys complémet
Amplification -> effecteur secondraire sur le site
Resolution-> inhibition et réparation

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5
Q

Facteur XII

A

Hageman

De la cagulation

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6
Q

Hémostase primire

A
Activation plaquette
Caillot 
Saignemeny limité
Propagation limité
Emprisonnt GR 
Stable plaquette
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7
Q

Complément lectne

A

Bact orga
Reco chaiine polysacch surface bact
MBL
FICOLINE

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8
Q

Voie classic complément

A

Anticorps dirigé contre une bact
Fixation anticorps surface bact
Activation C1q, C1r, C1S

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9
Q

Coomplément voie alternative

A

Permeanent dépos de prot a la surface c
C3 et fact B
Accéleration dépot prot si bact

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10
Q

Anaphylotoxine

A

C3a C5a

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11
Q

Mastocyte

A

C residente
Riche en granule -> m performé
+++ dans inflamation

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12
Q

Activation mastocyte par C5a

A

Degranulation
Liberation histaine = immdiat
Liberation autre m = retardé

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13
Q

Autres m liberés mastocyte

A

Cytokine chémokine

Mediateur lip = pprosta thromboxane

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14
Q

Action médiateurlip infla sur c

A

Activation de PLA2 = Synth acide arachidonique à partir de PLmbr
Lipoxygénase sur arachidonate=> leucotriene B4 => chimiotactisme
Cox sur arachidonate => cox é = inflamation => synthe prosta + thromboxane

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15
Q

Monocyte

A

Circule sanf
Rond
≠ macro entrée c

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16
Q

Macro

A

Mononuclées
Pseudopode. = phago bact ou présenter antigene
Kupfer. = foie
Microgliale=. Microglie cerveau

17
Q

Polynucléaire neutrophile

A
Circule dans le sang ø c residente 
Polylobé = noyau 
2eme phase reponse inflam
Mort rapide
Pus quand il sont mort
18
Q

Hémogramme monocyte et PNN

A
Mono= 100-1000/mm3
PNN= 1500-7000/mm3
19
Q

Dilatation vasseaux

A
Histamine 
Bredyk
Prosta
C5a 
Oxyde nitrique, leuco, fact plaquettr, fmpl
20
Q

TLR3

A

Virus reconnu par ADN ou ARN

21
Q

TLR4

A

Bactéries

Lipoprot ou ADN

22
Q

Cytokine

A

Dialogue entre les c

23
Q

NFkB

A

Facteur de transcription maj de act c imm unitaire

24
Q

Cytokine antivirale

A

Production interferons

Interfere replication virus

25
Q

Chémokine

A

Petite cytokine recruteemet autre c inflamatoire

26
Q

Peptide antimicrobiens

A

Defensine = defendre contre infection

27
Q

NLRP3 inflammosome

A
Pyrin= chaleur fievre
Inflammosoe = NLRP3 + adaptateur+ caspase
28
Q

Arthrite goutterse = maladie de la goutte

A

Rhumatisme microcristallin= accumulation cristau acide urique dans articuation
Jamais dissous = lesion cr = inflamosome NLRP3

29
Q

Lysosome m toxique

A

Radiaux libre oxygénée

30
Q

Peptide antimicrobien

A

Défensine

Cathélicide

31
Q

Effet nociceptif

A

Douleur/ perception douler

32
Q

Sérotonine

A

Libeerer par activation plaqete

33
Q

Neurotrophine = NGF

A

Facteur de croissance

34
Q

Substance p

A

Activ c => degranuation masto

Vasodillatateur

35
Q

Selectine pref

A

Sucre

36
Q

LFA1

A

Integrine

PNN et c

37
Q

IG

A

Ap les integrie

IICAM1