Pathophysiology and Disease Processes Flashcards
pathophysiology
challenges in maintaining homeostasis and overall state of health
diabetes mellitus type 1
- endocrine
- autoimmune
- polyuria
- polydipsia
- fatigue
- blurry vision
- weight loss
- elevated blood glucose
- insulin therapy
diabetes mellitus type 2
-endocrine
-obesity
-inactivity
-genetics
-polyuria
-polydipsia
-fatigue
-elevated blood glucose
therapy:
-diet modification
-exercise
-medication
-insulin therapy
polycystic ovary syndrome (PCOS)
- endocrine
- excessive insulin
- irregular menses
- elevated hormone levels
- multiple cysts on ovaries
- weight loss
- estrogen and progestin
hypothyroidism
- endocrine
- autoimmune
- thyroid surgery
- fatigue
- weight gain
- muscle aches
- bradycardia
- depression
- elevated cholesterol
- dry skin
- synthetic thyroid hormone medication (levothyroxine)
hyperthyroidism
- endocrine
- graves disease
- thyroiditis
- plummers disease
- weight loss
- tachycardia
- anxiety
- fatigue
- sleep disruption
- goiter
- therapy:
- radioactive iodine
- antithyroid
- beta blockers
- thyroidectomy
basal cell carcinoma (BCC)
- integumentary
- light/fair skin
- sun exposure
- new growth or sore that does not heal
- curettage and electrodessication mohs surgery
- cryosurgery
- laser therapy
squamous cell carcinoma
- light/fair skin
- sun exposure
- less common than BCC
- spreads to surrounding tissue
- most common on face and head
- curettage and elctrodessication mohs surgery
- cryosurgery
- laser surgery
malignant melanoma
- integumentary
- light/fair skin
- sun exposure
- itchy/bleeding mole
- new mole
- mole with changes
- depends on stage of lesion
- surgery
- lymph node biopsy
- chemotherapy
- radiation therapy
- immunotherapy
acne vulgaris
- integumentary
- surge of sex hormones during puberty
- excess sebum on skin surface
- black heads, white heads
- papules
- pustles
- regular cleansing of affected area
- OTC benzoyl peroxide products
- prescriptions
alopecia
- integumentary
- often hereditary
- hormone changes
- chemotherapy
- stress
- burns
- fungal skin
- loss or lack of hair
- no cure
- hair transplants
- medications can slow progression
cellulitis
- integumentary
- staphylococcal and streptococcal bacterial infections
- red, tight skin
- pain in inflammed areas
- fever
- oral/topical antibiotics
- hospitilization if at risk for developing systemic infection
dermatitis
- integumentary
- multiple causative agents
- contacts with irritants
- inflammation of skin resulting in rash or pruritus
- corticosteroid creams
- oral steroids
eczema
- integumentary
- chronic dermatitis with vesicular eruptions
- itchy, scaly, red, rash
- topical or systemic seteroids
- NSAIDs for discomfort
folliculitis
- shaving or repeated rubbing of shaved area
- bacteria or fungi
- red, itchy, hair follicles
- pimple appearance
- regular cleansing of affected area
- topical antibiotics
- electric shaver
herpes simplex
- integumentary
- contact with herpes simplex virus
- type 1: painful blisters on lips, mouth
- type 2: similar lesions in genital area
- no cure
- antiviral medication to decrease frequency of outbreaks
lmpetigo
- integumentary
- staphylococcal and streptococcal bacteria
- itchy, oozing skin lesions with honey like appearing crust
- antibiotics
- frequent cleasning
pediculosis
- parasitic lice infestation
- skin itching
- nits (eggs) in hair
- particularly near roots
- prescription or OTC lice treaments/shampoo
psoriasis
- inherited autoimmune disorder
- silvery, scaly, severely itchy skin lesions
- systemic symptoms such as joint pain and imflammation
- oral NSAIDs
- topical creams
- vitamin A and D
- hydrocortisone cream
- UV treatment
ringworm
- contact with causative fungus
- flat, circular lesions
- topical and oral antifungal medication
rosacea
- dilation of small facial blood vessels
- redness
- acne like eruptions on face
- topical cortisones
- antibiotics
- vascular laser therapy
osteoarthritis
- musculoskeletal
- inflammatory
- metabolic disorder
- joint stiffness and pain
- fluid surrounding the joint
- grating sounds with joint movement
- NSAIDs intra-articular injections
- arthroscopy joint replacement surgery
rheumatoid arthritis
autoimmune
- destruction of the joint capsule causing scar tissue to form
- visible joint deformity
- loss of joint mobility
- NSAIDs
- exercise
- heat and cold
- cortisone injections
- surgery to remove scar tissue
bursitis
- musculoskeletal
- overuse
- joint trauma
- bacterial infection
- joint pain and swelling
- rest
- pain medication
- steroid medication
- aspiration of joint fluid
- antibiotics
ewings sarcoma family of tumors
- unknown
- males only
- 10-20 years old
- fever
- pain at tumor site
- fractures
- bruising
- surgery
- chemotherapy
- radiation therapy
- bone marrow transplant
- stem cell transplant
gout
musculoskeletal
- deposits of uric acid crystals accumulate in joint spaces
- joint pain
- common in big toe and knee joints
- stiffness
- swelling
- dietary changes
- pain medication
- medication to aid in elimination of uric acid in kidneys during urine formation
kyphosis
- growth retardation
- improper development of growth plates
- aging and degeneration disk disease
- visible upper back curvature
- exercise
- back bracing
- harrington rod
- spinal fusion in extreme cases
lordosis
- injury
- poor posture
- wearing high heels
- inward curvature of lower back
- corrective shoes
- exercise
osteogenesis imperfecta (brittle bone disease)
- hereditary
- dental issues
- fractures at birth
- loose joints
- muscle weakness
- respiratory issues
- blue sclera of the eyes
- triangle shaped face
- small stature
- spinal curvature
- fracture repair
- surgery with metal ordding
- physical therapy
- bracing
osteoporosis
- hormone deficiencies
- sedentary lifestyle
- lack of vit D
- corticosteroid use
- smoking
- fractures (spine, hips, wrists)
- loss of height
- kyphosis
- medication
- hormone replacement
- exercise
- supplements
osteosarcoma
- unknown
- pain in affected bones (usually legs)
- swelling with development of tumor growth
- surgery
- chemotherapy and radiation
- amputation of affected leg
pagets disease
- hereditary
- viral
- bone pain and deformity
- fractures
- excessive bone destruction
- surgery
- medication
- physical therapy
scoliosis
- genetic
- muscle weakness
- prenatally during formation of vertebrae
- bent appearing spine
- back pain
- back bracing
- physical therapy
- surgery with rod placement
fibromyalgia
- unknown
- exacerbated by sleep deprivation
- emotional distress
- depression
- fatigue
- point tenderness
- trigger points
- chronic facial pain
- sleep disturbances
- antidepressants
- NSAIDs
- physical therapy
- trigger point
- injections
muscular dystrophy
- hereditary
- muscle weakness leading to eventual paralysis of muscles
- physical therapy
- bracing
- ambulatory devices
- medications
myasthenia gravis
- autoimmune
- double vision
- muscle weakness
- dysphagia
- difficulty chewing
- difficulty breathing
- avoiding exercise
- stress
- rest
- eye patch
- medication
tendonitis
- sports or activity related
- pain in joints
- limited range of motion
- rest
- ice
- NSAIDs
tetanus
- toxin produced by clostridium tetani
- muscle spasm in jaw and neck
- dyspnea
- fever
- irritability
- sweating drooling
- antitoxin
- antibiotics
hypertension
- narrowing of arteries
- increased arterial pressure
- risk factors: obesity, smoking, stimulant use, kidney disease, high sodium intake, excessive alcohol consumption
- excessive sweating
- fatigue
- muscle cramps
- headaches
- dizziness
- treatment of underlying cause
- lifestyle change
- antihypertensive medication
angina
- coronary artery narrowing
- atherosclerosis
- pain/tightness in chest
- sublingual nitroglycerin
coronary artery disease (atherosclerosis)
- buildup of fat and cholesterol in arteries
- risk factors: high fat diet, high LDL, smoking, obesity, sedentary lifestyle
- no symptoms prior to heart attack
- lipid lowering medications
- low fat diet exercise
- smoking cessation
- coronary artery bypass grafting in severe cases
myocardial infarction (heart attack)
- coronary artery blockage
- atherosclerosis
- blood clot
- squeezing chest pain that can radiate to shoulder/arm/neck/jaw
- shortness of breath
- diaphoresis
- dizziness
- nausea
- aspirin
- CPR if unconscious
- defibrillation
- anticoagulant
- immediate emergency protocol
aneurysm
- atherosclerosis
- smoking
- high cholesterol
- diet obesity
- usually no symp
- possible back pain
- tachycardia
- dizziness
- surgery
congestive heart failure (CHF)
- smoking
- obesity
- sedentary lifestyle
- high cholesterol
- hypertension*
- shortness of breath
- wheezing
- peripheral edema in legs
- irregular heart beat
- medications to address tachycardia
- diuretic medication to treat edema
- antihypertensive medication
mitral valve prolapse
- unknown or hereditary
- mild cases usually have no symptoms
- severe cases can have shortness of breath and palpitations
- surgery
thrombophlebitis
- prolonged periods of inactivity
- hormone replacement therapy
- cancer paralysis
- thrombophlebitis
- pain in affected area
- redness
- swelling
- heat compression
- stockings
- anticoagulants medication surgery