Pathophysiology and Disease Processes Flashcards
pathophysiology
challenges in maintaining homeostasis and overall state of health
diabetes mellitus type 1
- endocrine
- autoimmune
- polyuria
- polydipsia
- fatigue
- blurry vision
- weight loss
- elevated blood glucose
- insulin therapy
diabetes mellitus type 2
-endocrine
-obesity
-inactivity
-genetics
-polyuria
-polydipsia
-fatigue
-elevated blood glucose
therapy:
-diet modification
-exercise
-medication
-insulin therapy
polycystic ovary syndrome (PCOS)
- endocrine
- excessive insulin
- irregular menses
- elevated hormone levels
- multiple cysts on ovaries
- weight loss
- estrogen and progestin
hypothyroidism
- endocrine
- autoimmune
- thyroid surgery
- fatigue
- weight gain
- muscle aches
- bradycardia
- depression
- elevated cholesterol
- dry skin
- synthetic thyroid hormone medication (levothyroxine)
hyperthyroidism
- endocrine
- graves disease
- thyroiditis
- plummers disease
- weight loss
- tachycardia
- anxiety
- fatigue
- sleep disruption
- goiter
- therapy:
- radioactive iodine
- antithyroid
- beta blockers
- thyroidectomy
basal cell carcinoma (BCC)
- integumentary
- light/fair skin
- sun exposure
- new growth or sore that does not heal
- curettage and electrodessication mohs surgery
- cryosurgery
- laser therapy
squamous cell carcinoma
- light/fair skin
- sun exposure
- less common than BCC
- spreads to surrounding tissue
- most common on face and head
- curettage and elctrodessication mohs surgery
- cryosurgery
- laser surgery
malignant melanoma
- integumentary
- light/fair skin
- sun exposure
- itchy/bleeding mole
- new mole
- mole with changes
- depends on stage of lesion
- surgery
- lymph node biopsy
- chemotherapy
- radiation therapy
- immunotherapy
acne vulgaris
- integumentary
- surge of sex hormones during puberty
- excess sebum on skin surface
- black heads, white heads
- papules
- pustles
- regular cleansing of affected area
- OTC benzoyl peroxide products
- prescriptions
alopecia
- integumentary
- often hereditary
- hormone changes
- chemotherapy
- stress
- burns
- fungal skin
- loss or lack of hair
- no cure
- hair transplants
- medications can slow progression
cellulitis
- integumentary
- staphylococcal and streptococcal bacterial infections
- red, tight skin
- pain in inflammed areas
- fever
- oral/topical antibiotics
- hospitilization if at risk for developing systemic infection
dermatitis
- integumentary
- multiple causative agents
- contacts with irritants
- inflammation of skin resulting in rash or pruritus
- corticosteroid creams
- oral steroids
eczema
- integumentary
- chronic dermatitis with vesicular eruptions
- itchy, scaly, red, rash
- topical or systemic seteroids
- NSAIDs for discomfort
folliculitis
- shaving or repeated rubbing of shaved area
- bacteria or fungi
- red, itchy, hair follicles
- pimple appearance
- regular cleansing of affected area
- topical antibiotics
- electric shaver
herpes simplex
- integumentary
- contact with herpes simplex virus
- type 1: painful blisters on lips, mouth
- type 2: similar lesions in genital area
- no cure
- antiviral medication to decrease frequency of outbreaks
lmpetigo
- integumentary
- staphylococcal and streptococcal bacteria
- itchy, oozing skin lesions with honey like appearing crust
- antibiotics
- frequent cleasning
pediculosis
- parasitic lice infestation
- skin itching
- nits (eggs) in hair
- particularly near roots
- prescription or OTC lice treaments/shampoo
psoriasis
- inherited autoimmune disorder
- silvery, scaly, severely itchy skin lesions
- systemic symptoms such as joint pain and imflammation
- oral NSAIDs
- topical creams
- vitamin A and D
- hydrocortisone cream
- UV treatment
ringworm
- contact with causative fungus
- flat, circular lesions
- topical and oral antifungal medication
rosacea
- dilation of small facial blood vessels
- redness
- acne like eruptions on face
- topical cortisones
- antibiotics
- vascular laser therapy
osteoarthritis
- musculoskeletal
- inflammatory
- metabolic disorder
- joint stiffness and pain
- fluid surrounding the joint
- grating sounds with joint movement
- NSAIDs intra-articular injections
- arthroscopy joint replacement surgery
rheumatoid arthritis
autoimmune
- destruction of the joint capsule causing scar tissue to form
- visible joint deformity
- loss of joint mobility
- NSAIDs
- exercise
- heat and cold
- cortisone injections
- surgery to remove scar tissue
bursitis
- musculoskeletal
- overuse
- joint trauma
- bacterial infection
- joint pain and swelling
- rest
- pain medication
- steroid medication
- aspiration of joint fluid
- antibiotics
ewings sarcoma family of tumors
- unknown
- males only
- 10-20 years old
- fever
- pain at tumor site
- fractures
- bruising
- surgery
- chemotherapy
- radiation therapy
- bone marrow transplant
- stem cell transplant
gout
musculoskeletal
- deposits of uric acid crystals accumulate in joint spaces
- joint pain
- common in big toe and knee joints
- stiffness
- swelling
- dietary changes
- pain medication
- medication to aid in elimination of uric acid in kidneys during urine formation
kyphosis
- growth retardation
- improper development of growth plates
- aging and degeneration disk disease
- visible upper back curvature
- exercise
- back bracing
- harrington rod
- spinal fusion in extreme cases
lordosis
- injury
- poor posture
- wearing high heels
- inward curvature of lower back
- corrective shoes
- exercise
osteogenesis imperfecta (brittle bone disease)
- hereditary
- dental issues
- fractures at birth
- loose joints
- muscle weakness
- respiratory issues
- blue sclera of the eyes
- triangle shaped face
- small stature
- spinal curvature
- fracture repair
- surgery with metal ordding
- physical therapy
- bracing
osteoporosis
- hormone deficiencies
- sedentary lifestyle
- lack of vit D
- corticosteroid use
- smoking
- fractures (spine, hips, wrists)
- loss of height
- kyphosis
- medication
- hormone replacement
- exercise
- supplements
osteosarcoma
- unknown
- pain in affected bones (usually legs)
- swelling with development of tumor growth
- surgery
- chemotherapy and radiation
- amputation of affected leg
pagets disease
- hereditary
- viral
- bone pain and deformity
- fractures
- excessive bone destruction
- surgery
- medication
- physical therapy
scoliosis
- genetic
- muscle weakness
- prenatally during formation of vertebrae
- bent appearing spine
- back pain
- back bracing
- physical therapy
- surgery with rod placement
fibromyalgia
- unknown
- exacerbated by sleep deprivation
- emotional distress
- depression
- fatigue
- point tenderness
- trigger points
- chronic facial pain
- sleep disturbances
- antidepressants
- NSAIDs
- physical therapy
- trigger point
- injections
muscular dystrophy
- hereditary
- muscle weakness leading to eventual paralysis of muscles
- physical therapy
- bracing
- ambulatory devices
- medications
myasthenia gravis
- autoimmune
- double vision
- muscle weakness
- dysphagia
- difficulty chewing
- difficulty breathing
- avoiding exercise
- stress
- rest
- eye patch
- medication
tendonitis
- sports or activity related
- pain in joints
- limited range of motion
- rest
- ice
- NSAIDs
tetanus
- toxin produced by clostridium tetani
- muscle spasm in jaw and neck
- dyspnea
- fever
- irritability
- sweating drooling
- antitoxin
- antibiotics
hypertension
- narrowing of arteries
- increased arterial pressure
- risk factors: obesity, smoking, stimulant use, kidney disease, high sodium intake, excessive alcohol consumption
- excessive sweating
- fatigue
- muscle cramps
- headaches
- dizziness
- treatment of underlying cause
- lifestyle change
- antihypertensive medication
angina
- coronary artery narrowing
- atherosclerosis
- pain/tightness in chest
- sublingual nitroglycerin
coronary artery disease (atherosclerosis)
- buildup of fat and cholesterol in arteries
- risk factors: high fat diet, high LDL, smoking, obesity, sedentary lifestyle
- no symptoms prior to heart attack
- lipid lowering medications
- low fat diet exercise
- smoking cessation
- coronary artery bypass grafting in severe cases
myocardial infarction (heart attack)
- coronary artery blockage
- atherosclerosis
- blood clot
- squeezing chest pain that can radiate to shoulder/arm/neck/jaw
- shortness of breath
- diaphoresis
- dizziness
- nausea
- aspirin
- CPR if unconscious
- defibrillation
- anticoagulant
- immediate emergency protocol
aneurysm
- atherosclerosis
- smoking
- high cholesterol
- diet obesity
- usually no symp
- possible back pain
- tachycardia
- dizziness
- surgery
congestive heart failure (CHF)
- smoking
- obesity
- sedentary lifestyle
- high cholesterol
- hypertension*
- shortness of breath
- wheezing
- peripheral edema in legs
- irregular heart beat
- medications to address tachycardia
- diuretic medication to treat edema
- antihypertensive medication
mitral valve prolapse
- unknown or hereditary
- mild cases usually have no symptoms
- severe cases can have shortness of breath and palpitations
- surgery
thrombophlebitis
- prolonged periods of inactivity
- hormone replacement therapy
- cancer paralysis
- thrombophlebitis
- pain in affected area
- redness
- swelling
- heat compression
- stockings
- anticoagulants medication surgery
acquired immunodeficiency syndrome (AIDS)
- HIV virus
- low t cell counts
- fever
- diaphoresis
- susceptibility to frequent infection
- weight loss
- antiretroviral medication to slow progression
- treatment of secondary infections with antibiotics
- no cure
lymphedema
- parasitic infection
- trauma
- surgical removal of lymph nodes
- persistent tissue swelling
- compression stockings
- lymphedema pump
- surgery
mononucleosis
- epstein barr virus
- cytomegalovirus
- extreme fatigue
- sore throat
- fever
- supportive care
systemic lupus erythematosus
- medications bacterial infection
- autoimmune
- fatigue
- body pain
- butterfly rash on face
- headaches
- nausea
- hair loss
- weight loss
- anemia
- shortness of breath
- NSAIDs (steroids topical creams)
celiac disease
- genetic defect
- lack of enzyme that breaks down gluten
- consumption of gluten triggers
- autoimmune reaction
- weight loss
- bloating
- loose stools
- eventual systemic organ wasting due to lack of nutrients
- malabsorption
- gluten free diet
asthma
- allergens
- pollutants
- dust mites
- cigarette smoke
- wheezing
- coughing
- feeling of tightness in chest
- avoiding allergens/irritants
- rescue inhaler of bronchodilation
- anti inflammatory steroid inhalers
- leukotrienereceptor antagonists
- steroid injection for an acute episode
atelectasis
- cystic fibrosis
- COPD
- lung cancer
- spontaneous
- dyspnea
- cyanosis
- diaphoresis
- pain
- thoracentesis
- chest percussion
- deep breathing exercises
- intermittent
- positive pressure breathing
bronchitis
- viral
- environmental pollutants
- cigarette smoke
- yellow gray or green productive cough
- chest tightness
- dyspnea
- fever
- cough medicine
- humidifier
- inhalers
- antibiotics in some cases
chronic obstructive pulmonary disease (COPD)
- smoking environmental pollutants
- dyspnea
- hypoxia
- fatigue
- cough
- smoking cessation
- inhalers
- lung transplant in extreme cases
emphysema
- damage to the alveoli caused by cigarette smoke
- pollutants
- specific types of dust
- shortness of breath
- chronic cough
- fatigue
- smoking cessation
- avoiding cold environments
- antibiotics for secondary lung infections
influenza
- respiratory virus
- fever
- muscle pain
- fatigue
- sore throat
- rhinorrhea
- symptomatic
- OTC analgesics for aches and fever
- antiviral medication
legionnaires’ disease
- legionella bacteria that grow in standing water
- dyspnea
- cough
- headache
- fever
- antibiotics
- respiratory medications
- oxygen
- fever medication (antipyretic)
pneumonia
- bacterial
- viral
- parasitic
- thick, colored sputum
- dyspnea
- fever
- cough
- rest
- antibiotics
- OTC analgesics
pulmonary edema
- congestive heart failure
- myocardial infarction
- heart valve disorder
- drowning injury
- orthopnea
- dyspnea
- wheeze
- productive cough
- weight gain
- pallor
- oxygen therapy
- diuretics
pulmonary embolism
- blood clot blocking an artery in the lung
- dyspnea
- chest pain
- cough
- fainting
- rapid onset of shortness of breath
- diaphoresis
- circulation support (compression hose)
- rest
- anticoagulant medication
- surgically implanted filter
severe acute respiratory syndrome (SARS)
- viral
- fever
- headache
- dry cough
- rest
- antiviral medication
tuberculosis (TB)
- bacterial
- chronic cough
- weight loss
- fatigue
- night sweats
- painful or difficult breathing
- isolation if symptomatic medication therapy for 6 to 12 months
alzheimers disease
- degenerative brain disease
- genetic or environmental
- confusion
- memory loss
- impaired judgement
- personality change
- worsens overtime
- physical activity
- socialization
- medication to slow the progression
- no cure
bells palsy
- unknown cause
- weakness or paralysis of facial muscles
- facial numbness
- headache
- NSAIDs
- pain relievers
- usually self resolving
seizures
- birth trauma
- infections
- brain injury
- head trauma
- drug withdrawal
- uncontrolled muscle contractions
- loss of consciousness
- visual disturbances
- medication
- brain surgery
meningitis
- bacterial
- viral
- fungal
- infection
- inflammation of meninges
- stiff neck
- headache
- fever
- vomiting
- appropriate medication
- bacterial can be fatal
multiple sclerosis (MS)
- viral
- genetic
- immune system dysfunction
- loss of ability to speak, walk
- double vision
- loss of balance
- weakness in arm/legs
- supportive medications to slow
- no cure
parkinsons disease
- lack of neurotransmitters
- brain tumors
- drugs
- head trauma
- arm/leg muscle and joint stiffness
- lack of coordination
- tremor
- supportive medications to slow progression
- no cure
stroke
- blockage of artery in neck or brain
- paralysis
- confusion
- memory impairment
- symptoms can be permanent
- physical therapy
- occupational therapy
- speech therapy
migraine headache
hormones
- stress
- dietary
- familial
- dull to throbbing
- head pain
- sensitivity to light, sound, nausea, vomiting
- visual aura
- medications alternative methods (acupunture, biofeedback, magnesium)
benign prostatic hyperplasia (BPH)
- increased age
- increased level of dihydrotestosterone
- feeling of full bladder after urinating
- weak urine flow
- needing to urinate often
- alpha blockers
- minimally invasive surgical procedures
- transurethral resection of the prostate (TURP)
hydrocele
- failure of inguinal ring to close properly in development
- injury or swelling of the scrotum
- few symptoms
- pain
- increased size of scrotum
- surgery if symptomatic
prostate cancer
- unknown
- genetics
- pain
- erectile dysfunction
- dysuria
- hormone therapy
- radiation therapy
- surgery
- cryosurgery
- chemotherapy
sexually transmitted infections
- unprotected contact with infected tissue or fluids
- varies depending on infection/disease
- pelvic or penile pain
- sores
- itching or discharge
- dysuria
- body rash
- infertility
- varies depending on infection/disease
- medication crysurgery
- immunizations
endometriosis
- unknown
- almost no symptoms
- pelvic pain especially during menses
- painful urination and defecation
- infertility issues
- NSAIDs
- gonadotropin releasing hormone
- oral contraceptives
- progestins
- surgical intervention
pelvic inflammatory disease
- untreated STDs/STIs
- multiple sexual partners
- frequent douching
- lower abdominal pain
- back pain
- fever
- rapid pulse
- vaginal discharge
- pain during sex
- antibiotic treatment
- surgical intervention to treat scarring
cervical cancer
- particular strains of human papillomavirus (HPV)
- abnormal vaginal bleeding
- lower abdominal or pelvic pain
- abnormal vaginal discharge
- pain during sex
- surgical intervention (partial or complete hysterectomy)
- removal of lymph nodes in affected regions
- chemotherapy
- radiation therapy
acute kidney failure
- burns
- dehydration
- hemorrhage
- low blood pressure
- trauma
- little to no urine production
- swelling in extremities
- mental confusion
- coma
- seizures
- nose bleeds
- increase dietary protein
- fluid and potassium
- intake regulation dialysis
chronic kidney disease
- diabetes
- hypertension
- kidney stones
- polycystic kidney disease
- headache
- seizures
- confusion
- fatigue
- anemia
- abnormal heart or lung sounds
- antibiotics
- blood transfusion
- control of blood pressure
- dialysis
- kidney transplant
incontinence
- nervous system disorders
- urinary tract infection (UTI)
- bladder cancer
- prostate disorders
- involuntary urination
- medication
- surgical removal of the prostate
- kegel exercises
- surgery
polycystic kidney disease
- enlarged kidneys due to cysts
- inherited
- hypertension
- fatigue
- anemia
- heart murmurs
- medication draining of cysts
- surgical removal of kidneys
pyelonephritis
- bladder infection that spreads to kidney
- fatigue
- fever
- painful urination
- cloudy or bloody urine
- antibiotics
renal calculi
- highly concentrate urine
- UTI
- gout
- severe back or abdominal pain
- fever
- nausea
- urgency
- medication
- surgery
- lithotripsy
appendicitis
- idiopathic
- inflammation of the appendix
- RLQ pain loss of appetite nausea
- antibiotics
- appendectomy
cirrhosis
- scarring of liver
- can be autoimmune
- medication
- alcohol
- hepatitis B or C
- anemia
- fatigue
- fever
- enlarged liver
- jaundice
- weight loss
- avoid alcohol consumption
- antibiotics
- diuretics
cholelithiasis (gallstones)
- insoluble cholesterol and bile salt
- can be asymptomatic
- radiating right upper quad pain
- fever
- nausea, vomiting
- laparoscopic cholecystectomy
- lithotripsy
colitis (inflammation of the large intestine)
- viral or bacterial infection
- diarrhea
- abdominal pain
- bloating
- treatment of underlying cause
- surgery
constipation (difficulty eliminating feces)
- inactivity
- lack of fiber and water in diet
- medications
- bloating
- abdominal pain
- hard feces
- increased dietary fiber and water
- physical activity
crohns disease
- inflammatory bowel disease
- autoimmune
- fever
- joint pain
- tender gums
- abnormal abdominal sounds
- constipation or diarrhea
- intestinal bleeding
- dietary changes antibiotics
- surgery
diverticulitis (abnormal outpouching of intestinal wall)
- bacterial
- viral
- parasitic
- constipation or diarrhea
- bloody stools
- abdominal pain
- nausea
- high fiber diet
- antibiotics
hemorrhoids (varicose vein of the rectum or anus)
- constipation
- straining during bowel movements
- pelvic pressure during pregnancy, childbirth
- itching, pain in anal area
- blood with bowel movements
- visible protrusion from the anus
- high fiber diet
- stool softeners
- surgical removal
hiatal hernia (part of stomach protrudes through diaphragm into chest cavity)
- unknown causes
- smoking
- obesity
- heart burn
- chest pain
- excessive burping
- nausea, vomiting
- weight reduction
- medication
- surgical repair
stomach ulcer
- bacterial infection
- smoking
- medication
- nausea, vomiting
- abdominal pain
- antibiotics
- antacid medication
- surgery
anterior cruciate ligament (ACL) tear
- plant and twist motion of the foot and knee
- pain
- swelling
- knee buckling
- physical exam
- radiographic confirmation (MRI)
- RICE
- surgical repair
- allograft
- physical therapy
concussion
- head impact
- nausea
- loss of balance
- disorientation
- headache
- physical exam
- neurologic testing
- CT of the brain
- rest
- treatment of symptoms
muscle strain
- overexertion of a muscle not properly warmed up for activity level
- pain
- swelling
- tight feeling
- physical exam
- MRI
- RICE
- avoiding physical strain to the area
epicondylitis (tennis elbow)
- overuse of elbow causing tiny ligament tears
- swelling
- tenderness
- grip weakness
- physical exam
- x-ray
- MRI
- rest
- ice
- NSAIDs
- forearm strap
- extended break from aggravating activity
rotator cuff tear
- repetitive stress of the shoulder joint
- pain
- weakness
- inability to raise arm over head
- physical exam
- x-ray
- MRI
- rest
- NSAIDs
- cortisone injection to shoulder joint
- surgery
bone fracture
- impact injury resulting in bone cracking or breaking
- stress fractures- overuse or repetitative stress
- pain
- swelling
- loss of function
- physical exam
- x-ray
- CT if plain films are not clear
- immobilization with internal or external device (Cast, splint, pins, plates, screws)
joint dislocation (subluxations)
- impact injury removing bones from the proper joint alignment
- pain
- loss of sensation
- immobility
- physical exam
- x-ray
- MRI
- CT
- realignment of bones
- immobilization
- physical therapy to strengthen surrounding muscles
- surgery for repeated incidences
diagnostic imaging that uses radiation
- x-rays
- computed tomography (CT)
- angiography
- mammography
- nuclear medicine studies
diagnostic imagine that doesnt uses radition
- magnetic resonance imaging (MRI)
- ultrasound
contrast material
- makes structures more radiopaque (lighter/bright) -> easier to see
- air
- barium
- gadolinium
- iodine
- administered orally, infection or intravenously
nuclear medicine
- diagnostic imagine that involves administration of radioactive isotopes
- collects in areas of high metabolic activity
- SPECT scan- assess brain damage following stroke
- PET scan- diagnose brain disorders
- MUGA scan- evaluates condition of heart muscle
incidence
- occurrence of new diseases or cases in a specific population over a distinct time period
- incidence of injuries can be classified into groups of people who participate in specific activities
- ex. college athletes suffer from ACL tear more than kindergarten teachers
- new cases*
prevalence
- proportion of population who have a particular disease at a specific point in time over a period of time
- includes all cases while incidence is limited to only new cases
risk factors
- characteristics that make a person more likely to suffer a disease or injury
- modifiable or nonmodifiable
- high fat diet is a risk factor for heart disease and is modifiable
- family history of breast cancer is a nonmodifiable risk factor
morbidity
- measure of sickness or disease within a specific population or area
- morbidity can lead to mortality
mortality
- measure of deaths in an area of population
- morbidity can lead to mortality
comorbidities
- diseases or conditions in one person at the same time
- often chronic
- obesity, heart disease, and diabetes mellitus are common comorbid conditions
upstream management
- health care organizations becoming increasingly involved in the health of its population, even when patients are not in the clinic or hospitals
- community outreach programs, education, involvement of health care organization
endemic
-constantly present within a community
epidemic
infectious disease spreads rapidly to a large number of people
-can turn into a pandemic if measures are not taken to keep illness under control
pandemic
-world wide outbreak of a disease
smallpox
-pandemic that led to first vaccine
colorectal cancer
-risk factors are low fiber high fat diet, genetic, and being 55+