Pathology of The Respiratory System – Part 2 Flashcards
Name the different patterns of pneumonia.
B: most likely associated with bacterial infection.
C: a lot of fibrin –> More severe than supp
D: most likely associated with viral infections or pneumotoxins.
Toxins can produce pneumonia in the lungs via two routes. Name them.
- Aerogenous route
- hematogenous route.
Infectious Bovine Rhinotracheitis (IBR) is caused by
BoHV-1.
____________ virus (? virus) and _____ virus (?) cause a transient rhino-tracheitis and broncho-interstitial pneumonia with the formation of eosinophilic intracytoplasmic inclusions bodies in bronchial, bronchiolar, alveolar epithelial cells and alveolar macrophages.
Formation of syncytial cells occurs in ?
Para-influenza-3, PI-3, Bovine Respiratory Syncytial, BRSV
both, BRSV and PI-3 virus infection.
BRSV and PI-3 should be considered in calves with?
necrotizing bronchiolitis
Diagnosis of viral pneumonias are confirmed by ?
virus isolation, PCR or detection of viral antigens
by fluorescence antibody test (FAT) or immunohistochemistry (IHC).
BRSV
No clear areas of consolidation
Lungs appear to be larger, with more rubbery consistency, rib impressions (so see impression = virus, toxin).
BRSV
Bronchiole containing necrotic debris in lumen.
Pink cytoplasmic inclusion body can be seen in BRSV and Parainfluenza3 (in comparison to IBR = IN).
Microscopically can not differentiate between BRSV and PI3, need to do PCR.
BRSV
Syncytial cells
BRSV. IHC stains demonstrates widespread injury to the airway Epithelium.
Broncho interstial - virus damages bronchoioles and interstitium.
BRSV
Large syncytial cells that start partially dividing; contain same cytoplasm but multiple nuclei.
- Based on the image below, this cow suffered from?
- This condition is caused by what etiologic agent?
- Bovine enzootic pneumonia (chronic
suppurative bronchopneumonia). - Caused by a variety of etiologic agents
including respiratory viruses, Mycoplasmas,
Chlamydophila, followed by opportunistic
bacteria such as Pasteurella multocida,
Trueperella pyogenes, Histophilus somni,
Mannheimia haemolytica and E.coli.
❑ Calves with bovine leukocyte adhesion
deficiency (BLAD), which prevents the
migration of neutrophils from the
capillaries, are highly susceptible to
bronchopneumonia.
Chronic suppurative bronchopneumonia