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Pathology of Non-Hodgkin Lymphoma Flashcards

1
Q

Multiple myeloma is positive for what protein markers?

A

CD38+, CD138+

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2
Q

True/False. Non-aggressive types of non-Hodgkin lymphoma are often not curable.

A

True - they are less responsive to chemotherapy than aggressive NHLs

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3
Q

This type of non-Hodgkin lymphoma has a “starry sky” appearance on histology.

A

Burkitt Lymphoma

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4
Q

Diffuse Large B-Cell lymphoma with this molecular marker carry the worst prognosis.

A

MYC tanslocations

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5
Q

What is the immunephenotype for mantle cell lymphoma?

A

CD20+, CD5+, CyclinD1/BCL1+

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6
Q

What chromosomal translocation causes Burkitt lymphoma and the corresponding effect?

A

t(8;14) causing upregulation of c-MYC

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7
Q

True/False. Non-Hodgkin lymphomas are more likely to remain in a set of lymph nodes.

A

False - NHL is more likely to appear sporadically, whereas Hodgkin lymphoma presents regionally

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8
Q

What chromosomal translocation causes the non-Hodgkin lymphoma associated with MALT (mucosa-associated lymphoid tumors)?

A

Marginal Zone Lymphoma - t(11;18)

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9
Q

What is Waldenstrom macroglobulinemia?

A

A hyperviscosity syndrome caused by hypersecretion of IgM in lymphoplasmacytic lymphoma

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10
Q

What virus is present in nearly all cases of Burkitt Lymphoma?

A

EBV

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11
Q

A patient is diagnosed with a type of non-Hodgkin lymphoma that is CD30+ and has rearrangements of ALK and wreath cells on histology. What is the diagnosis?

A

Anaplastic T-Cell Lymphoma

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12
Q

Follicular lymphoma is most common in what age population?

A

Older adults

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13
Q

Excess free light chains are excreted in the urine by patients with multiple myeloma. What are these chains called?

A

Bence Jones Proteins

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14
Q

This plasma cell disorder is an early stage of multiple myeloma development.

A

Monoclonal Gammopathy of Undetermined Significance (MGUS)

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15
Q

Cells in the germinal center of a lymph follicle generally stain positive for what CD marker?

A

CD10+

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16
Q

What is the clinical presentation of multiple myeloma?

A

Hypercalcemia, renal dysfunction, anemia, bone lesions

17
Q

Lymphoplasmacytic lymphoma is associated with mutations of what gene?

A

MYD88 - increases NF-kB activity

18
Q

Follicular lymphoma stains positive for what immune markers?

A

CD20+, CD10+, BCL2+

19
Q

An M spike due to monoclonal M on a serum protein electrophoresis is characteristic of what type of lymphoma?

A

Multiple Myeloma

20
Q

What is the immunohistological profile of the non-Hodgkin lymphoma with “soccer ball” nuclei?

A

Small Lymphocytic Leukemia - CD20+, CD5+, CD23+

21
Q

What is the clinical presentation of Burkitt lymphoma?

A

Endemic BL - tumor of the jaw and face

Sporadic BL - abdominal masses

22
Q

Upregulation of BCL6 is most association with what lymphoma type?

A

Diffuse Large B-Cell Lymphoma (also BCL2+ and MYC+ in some cases)

23
Q

Patients with multiple myeloma have high amounts of what antibody chains?

A

IgG heavy chain and kappa light chain

24
Q

What is the most common and deadly plasma cell neoplasm?

A

Multiple myeloma

25
Q

What is the most common type of non-Hodgkin lymphoma?

A

Diffuse Large B-Cell

26
Q

What bones are most commonly affected by multiple myeloma?

A

Vertebral column

27
Q

What chromosomal translocation is associated with Follicular Lymphoma the result?

A

t(14;18) leading to upregulation of BCL2

28
Q

What is the histologic appearance of mantle cell lymphoma?

A

Thickened and expanded mantle zone with irregular lymphocytes

29
Q

This is a B-cell neoplasm in which cells undergo differentiation to plasma cells and secrete IgM.

A

Lymphoplasmacytic Lymphoma

30
Q

This type of non-Hodgkin lymphoma is due to a t(11;14) that causes overexpression of cyclin D.

A

Mantle Cell Lymphoma

31
Q

Smudge cells characterize chronic lymphocytic leukemia. What cells characterize the tissue version of CLL?

A

Small Lymphocytic Lymphoma - cells with soccer ball nuclei

32
Q

Cells in the mantle zone of lymph follicles generally stain positive for what CD marker?

33
Q

What is tumor lysis syndrome and what non-Hodgkin lymphoma is most associated with the disorder?

A

Burkitt Lymphoma - Tumor lysis syndrome is massive tumor cell lysis causing hyperuricemia, hyperuricosuria, hyperkalemia, and hypophophatemia that leads to renal failure

34
Q

This type of non-Hodgkin lymphoma presents with diffuse sheets of mature B cells.

A

Diffuse Large B-Cell Lymphoma

35
Q

What histological findings are characteristic of multiple myeloma?

A

Flame cells and Mott cells and Russell or Dutcher bodies

36
Q

This is a common indolent non-Hodgkin lymphoma that presents with hyperplasia of mature B cells in the germinal centers.

A

Follicular Lymphoma

Hematology/Oncology (18 decks)

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