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Hematology/Oncology > Drugs for Leukemia & Lymphoma > Flashcards

Drugs for Leukemia & Lymphoma Flashcards

1
Q

What ADR is associated with Brentuximab Vedotin?

A

Peripheral Neuropathy

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2
Q

This drug is used to treat any CD30+ neoplasm.

A

Brentuximab vedotin

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3
Q

What is the MOA of vedotin used with Brentuximab?

A

Anti-tubulin agent in addition to the anti-CD30 antibody action of Brentuximab

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4
Q

What is the MOA of cyclophosphamide?

A

DNA alkylating agent

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5
Q

What is the antidote for hemorrhagic cystitis caused by cycophosphamide?

A

Mesna

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6
Q

What drug is used to treat hairy cell leukemia?

A

Cladribine

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7
Q

This drug is a JAK inhibitor.

A

Ruxolitinib

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8
Q

What drugs are included in the ABVD regimen?

A

Doxorubicin, Belomycin, Vinblastine, Dacarbazine

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9
Q

This drug is given as prophylaxis to prevent tumor lysis syndrome.

A

Allopurinol

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10
Q

What is the treatment for acute promyelocytic leukemia?

A

All-trans Retinoic Acid (ATRA)

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11
Q

What ADR is associated with all-trans retinoic acid?

A

Differentiation Syndrome - fever, fluid overload, breathing issues, organ damage

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12
Q

What is the drug of choice for longterm management of chronic lymphatic leukemia?

A

Chlorambucil

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13
Q

This drug is used to treat any CD20+ positive neoplasm.

A

Rituximab

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14
Q

What drug are included in the R-CHOP regimen?

A

Rituximab (if CD20+), Cyclophosphamide, Doxorubicin, Vincristine, Prednisone

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15
Q

This DNA chelating agent is associated with cardiotoxicity.

A

Daunorubicin

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16
Q

What is the treatment for CML or AML due to the Philadelphia chromosome?

A

Imatinib

17
Q

Infusion reactions are an ADR associated with this drug use to treat leukemia & lymphoma.

A

Rituximab

18
Q

What is the MOA of methotrexate.

A

Inhibits the dihydrofolate reductase

19
Q

This treatment regimen is used to treat Hodgkin lymphoma.

A

ABVD

20
Q

What ADR is associated with imatinib?

A

Fluid retention

21
Q

This drug to treat CLL & NHL is associated with tumor lysis syndrome.

A

Bendamustine

22
Q

What are the clinical indications for Ruxolitinib?

A

Myelofibrosis, Polycythemia Vera

23
Q

This drug is used as an antidote for methotrexate.

A

Leucovorin

24
Q

What is the MOA an ADR or Belomycin?

A

MOA: Fragmentation of DNA

ADR: Pulmonary fibrosis

25
Q

What regimen is used to treat non-Hodgkin lymphoma?

A

R-CHOP

26
Q

Wha tis the MOA and ADR of Vincrisine?

A

MOA: Microtubule inhibition

ADR: Peripheral nueropathy

27
Q

What is the MOA of all-trans retinoic acid?

A

Stimulates maturation of neutrophils, which are then destroyed by the body due to neutrophilia

28
Q

What is the MOA of Dacarbazine?

A

DNA alkylating agent

29
Q

What drug is used to prevent differentiation syndrome?

A

Dexamethasone

30
Q

What is the MOA of Vinblastine?

A

Microtubule inhibition

31
Q

What is the MOA of imatinib?

A

Inhibits the tyrosine kinase

Hematology/Oncology (18 decks)

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