Pathology of Hodgkin Lymphoma Flashcards
What are Reed-Sternberg cells?
Characteristic of classic Hodgkin lymphoma, they are damaged B cells that do not express their antibody and support the growth and survival of tumor cells
Reed-Sternberg cells are positive for what markers?
CD15+, CD30+, PAX5+
Non-classic Hodgkin lymphoma does not present with Reed-Sternberg cells. What cells are present?
L&H (popcorn cell)
Hodgkin lymphoma arises from what cell type?
B cells
This type of Hodgkin lymphoma has fibrous bands, nodules, and lacunar “lake-like” RS cells.
Nodular Sclerosis
How does Hodgkin and non-Hodgkin lymphoma differ?
This type of classic Hodgkin lymphoma is dominated by T cells, with few RS cells present.
Lymphocyte-Rich
What are the characteristic “B symptoms?”
Fever, night sweats, weight loss
This is a type of Lanergans Cell Histiocytosis that presents in young children with calvarial bone defects, diabetes insipidus, and exophthalmos (protruding eyes).
Hand-Schuller-Christian Disease
This is the least common type of classic Hodgkin lymphoma, primarily presenting with RS cells, necrosis, and fibrosis.
Lymphocyte-Depleted
Diagnosis with what type of Hodgkin Lymphoma confers the best prognosis?
Nodular sclerosis
What transcription factor is activated in Hodgkin lymphoma?
NF-kB
What proteins are expressed by Langerhans cells?
S-100 protein and CD1a
True/False. Flow cytometry is generally not useful for diagnosing Hodgkin lymphoma.
True - neoplastic cells are in the minority
These cells are described as having an “owl eye” appearance.
Reed-Sternberg Cells