Pathology of Hodgkin Lymphoma Flashcards
What are Reed-Sternberg cells?
Characteristic of classic Hodgkin lymphoma, they are damaged B cells that do not express their antibody and support the growth and survival of tumor cells
Reed-Sternberg cells are positive for what markers?
CD15+, CD30+, PAX5+
Non-classic Hodgkin lymphoma does not present with Reed-Sternberg cells. What cells are present?
L&H (popcorn cell)
Hodgkin lymphoma arises from what cell type?
B cells
This type of Hodgkin lymphoma has fibrous bands, nodules, and lacunar “lake-like” RS cells.
Nodular Sclerosis
How does Hodgkin and non-Hodgkin lymphoma differ?
This type of classic Hodgkin lymphoma is dominated by T cells, with few RS cells present.
Lymphocyte-Rich
What are the characteristic “B symptoms?”
Fever, night sweats, weight loss
This is a type of Lanergans Cell Histiocytosis that presents in young children with calvarial bone defects, diabetes insipidus, and exophthalmos (protruding eyes).
Hand-Schuller-Christian Disease
This is the least common type of classic Hodgkin lymphoma, primarily presenting with RS cells, necrosis, and fibrosis.
Lymphocyte-Depleted
Diagnosis with what type of Hodgkin Lymphoma confers the best prognosis?
Nodular sclerosis
What transcription factor is activated in Hodgkin lymphoma?
NF-kB
What proteins are expressed by Langerhans cells?
S-100 protein and CD1a
True/False. Flow cytometry is generally not useful for diagnosing Hodgkin lymphoma.
True - neoplastic cells are in the minority
These cells are described as having an “owl eye” appearance.
Reed-Sternberg Cells
This cell type is morphologically characteristic of Hodgkin lymphoma.
Reed-Sternberg cells
This is the second-most common type of classic Hodgkin lymphoma, with biphasic age presentation and often EBV+.
Mixed Cellularity
True/False. Classical Hodgkin lymphoma is CD45-, while non-classical Hodgkin Lymphoma is CD45+.
True
Non-classical Hodgkin Lymphoma has L&H “popcorn cells.” What is the IHC stain profile?
CD20+, CD15-. CD30-
When does Hodgkin lymphoma generally present?
20-40yo
This type of Hodgkin lymphoma presents with scattered neoplastic cells in follicles of dendritic cells and lymphocytes.
Nodular Lymphocyte Predominant Hodgkin Lymphoma (Non-Classical)
