Non-Neoplastic White Cell Disorders Flashcards
Atypical lymphocytes and a positive heterophile antibody test are suggestive of what infection?
Infectious mononucleosis due to EBV infection
How can LAP score be used to differentiate leukomoid reactions from chronic myeloid lymphoma?
With a leuomoid reaction, LAP is normal or high. With CML, LAP is low
This is an increase in the number of white blood cells.
Leukocytosis
Pelger-Huet is a congenital qualitative disorder of neutrophils. How do these neutrophils appear histologically?
Hyposegmented (only 2 nuclei), look like sunglasses
This is an autosomal recessive disorder that causes a defect in neutrophilic lysosomal trafficking and giant cytoplasmic granules.
Chediak-Higashi Syndrome
True/False.Leukemoid reactions are an early indication of leukemia.
False - they are non-neoplastic increases in leukocytes often due to infection or severe hemorrhage or hemolysis
This congenital neutrophilic anomaly is due to a lack of lysosomal enzymes capable of breaking down mucopolysaccharides.
Alder Reilly Anomaly
Identify.
Monocytes.
What triad characterizes May-Hegglin anomaly?
Thrombocytopenia, giant platelets, inclusion bodies
This is a decrease in all three peripheral blood lineages (WBC, RBC, platelets).
Pancytopenia
What are the most common causes of basophilia?
Myeloproliferative disorders, hypersensitivity, hypothyroidism
An increased in the number of band cells is called…?
A left shift
What is the most common cause of agranulocytosis?
Decreased production due to drug toxicity
What is a complication of eosinophilia?
Hypereosinophilic syndrome - causes necrosis or fibrosis and tissue damage
What is agranulocytosis?
Severe neutropenia
What is a band cell?
Immature neutrophil
