Pathology of Lung Cancer

Question 1

name the 4 common smoking associated types of lung tumour and % of lung cancers it accounts for

Answer 1

adenocarcinoma 35%
squamous carcinoma 30%
small cell carcinoma 25%
large cell carcinoma 10%

Question 2

what type of tumour is the most common for lung cancer?

Answer 2

adenocarcinoma

Question 3

what colour is adenocarcinoma with mucin?

Answer 3

blue

Question 4

what is type of lung tumour has the worst survival rate?

Answer 4

small cell carcinoma

Question 5

what is type of lung tumour has the best survival rate?

Answer 5

adenocarcinoma

Question 6

what is the main treatment option for small cell cancers

Answer 6

chemo

Question 7

what hormone does small cell cancer produce?

Answer 7

adrenocorticotropic hormone ACTH

Question 8

what hormone does squamous cancer produce?

Answer 8

parathyroid hormone PTH

Question 9

name two genetic rapid emerging resistances to small cell lung cancer

Answer 9

Oncogenes – myc

Tumour Suppressor Genes – p53, Rb, 3p

Question 10

what is the treatment for Large cell lung cancer?

Answer 10

surgery but also chemo and radio

Question 11

what does adenocarcinoma express?

Answer 11

thyoid transcription factor 1 TTF

Question 12

what does squamous Cell cancer express?

Answer 12

p63 and high molecular wt. cytokeratins

Question 13

name the genetic abnormalities for non small cell cancer

Answer 13

Oncogenes – myc, K-ras, her2(neu)

Tumour suppressor genes – p53, 1q, 3p, 9p, 11p, Rb

Question 14

what does TNM stand for and what does it do?

Answer 14

classification of malignant tumours

Question 15

how are tumours classified?

Answer 15

size
number of nodes involved
metastasis

Question 16

name 2 other lung neoplasms and where they found?

Answer 16

Carcinoid- neuroendocrine system

-Bronchial gland neoplasms (most often seen in salivary glands)

Question 17

a carcinoid has low/high grade malignancy?

Answer 17

low