Pathology of Lung Cancer Flashcards
1
Q
What two locations are involved in the carcinogenesis of the lung?
A
Carcinogenesis in the periphery and the central airways
2
Q
In the lung periphery, what process leads to development of carcinoma?
A
Bronchioalveloar epithelial stem cells transform into adenocarcinoma
3
Q
In the central airways what process leads to development of carcinoma?
A
Bronchial epithelial stem cells transform into squamous cell carcinoma
4
Q
What are the local effects of Lung Cancer?
A
- Bronchial obstruction
- Endogenous lipid pneumonia
- Infection/Abscess
- Bronchiectasis
- Pleural inflammation and malignancy
- Direct invasion
- Lymph node metastasis
5
Q
What are the distant effects of lung cancer?
A
- Secondary to local effects (neural and vascular)
- Paraneoplastic syndrome
- Clubbing
6
Q
What are the relative proportions of the different histological types of lung cancer?
A
Small cell lung carcinoma (15%)
NSCLC (85%) - not one disease - diagnostic term
7
Q
What are the typical aetiologies for lung cancer?
A
- Tobacco
- Asbestos
- Environmental radon
- Occupational exposure
- Air pollution
- Pulmonary fibrosis
