pathology Flashcards

1
Q

3 biochemical mechanisms of lead toxicity

sx in the neuro, GI, renal, and heme systems

A
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2
Q

hypersensitivity pneumonitis

actue vs chronic

lung histo

clin presentation and testing/labs

:vs - idiopathic pulmonary fibrosis

A
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3
Q

what are the four morphologic phases of this disease

A

D = lobar pneumonia

c= interstitial pulmonary fibrosis

e= chronic bronchitis

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4
Q

dx and etiology

A
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5
Q
A
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6
Q

diagnosis?

what is the histo picture showing

clinical presentation

A

lung= hilar adenopathy, fever, cough,

LAD= well formed, noncaseating granulomas

erythematous rash

uveitis

weight loss, night sweats, arthralgias

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7
Q

dx and etiology

A
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8
Q
A
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9
Q

EYE PATH

causes of

  • cotton wool spots + dot-blot hemorrhages
  • cotton wool spots with arteriolar narrowing and hard exudates
  • acute monoocular vision loss with cherry red spot @ macule and retinal pallor
  • insidious loss peripheral vision + enlarged retinal cup + pale optic disk
  • subretinal drussen and abn pigment
A
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10
Q

xVHL –> CAs in which systems

A
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11
Q
A
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12
Q
A

wegeners= necrotizing vasulitis (nasal ulcerations, sinusitis, hemoptysis) + RPGN –> = Wegener/GPA/c-ANCA

=probably Abs against neutrophil proteinase 3

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13
Q
A
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14
Q
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15
Q
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16
Q

desribe tumors and sx in:

  • tuberous sclerosis
  • NF1
  • NF2
  • VHL
    *
A
  • tuberous sclerosis
    • AD
    • corticol tubers & subependymal hamartomas in brain
    • cardiac rhabdomyoma
    • facial angiofibroma
    • ash-leaf patches on skin (lack pigment)
    • renal angiomyolipoma (contain BVs, sm. M, +fat)
  • NF1
    • neurofibromas
    • optic gliomas
    • pigmented nodules of iris (Lisch Nodules)
    • cutaenous hyperpigmented macules (cafe au lait spots)
  • NF2
    • bilateral acousting neuromas
    • multiple meningiomas, gliomas, ependymomas
  • VHL
    • cerebellar hemangioblastomas
    • retinal hemangiomas
    • liver cysts
    • bilateral RCC (clear cell type)
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22
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