Pathology

Question 1

define what vasculitis is

Answer 1

inflam of the vessels

Question 2

What are the specific antibodies in Kawasaki’s disease?

Answer 2

Anti endothelial

Question 3

What are the specific antibodies in ANCA

Answer 3

Anti-neutrophil cytoplasmic antibodies

Question 4

what does cANCA react with?

Answer 4

cANCA reacts with Proteinase 3 hence cANCA

Question 5

What does pANCA react with ?

Answer 5

Reacts with Myeloperoxidase

Question 6

What artery does giant cell arteritis affect?

Answer 6

Affects temporal artery

Question 7

Does a negative temporal biopsy rule out GCA?

Answer 7

No - because GCA is segmental with skip lesions so the diagnosis could therefore be missed

Question 8

what size of vessels are affected in Polyarteritis Nodosa?

Answer 8

it is a medium vessel vasculitis

Question 9

are patients with polyarteritis nodosa ANCA positive ?

Answer 9

no

Question 10

what organ is often spared in polyarteritis nodosa ?

Answer 10

the lungs

Question 11

what are patients with polyarteritis nodosa often positive for ?

Answer 11

1/3rd of patients have hepB positivity

Question 12

what is often affected in patients with polyarteritis nodosa ?

Answer 12

patients often have renal impairment

Question 13

describe the histological appearance of PAN

Answer 13

• Transmural necrotising inflammation
• Fibrinoid necrosis of vessel