Cortex 2 - Rheumatology Flashcards
what is the term arthropathy used to describe ?
disease of the joint
what does the term arthritis describe ?
inflammation of the joint
what does arthralgia describe ?
simply pain in a joint
what are the two main categories of arthritis ?
inflammatory and non-inflammatory arthritis (commonly osteoarthritis)
how can arthritis be further subdivided into more specific categories
use the tabel
what factor is characteristic of many rheumatological conditions and what are these conditions specifically referred to as ?
Autoantibody production
Tend to be referred to as seropositive conditions (auto-antibodies in serum).
what are auto-antibodies ?
Are antibodies generated by the immune system against the body’s own proteins. If the immune system loses its normal regulatory processes, it stops recognising these proteins as being its own. It perceives them as alien and then begins to form antibodies against them, as it would an external threat eg. a virus.These auto-antibodies then begin to attack various organs and tissues, causing inflammation and damage.
Some autoantibodies are organ specific eg. those causing auto-immune thyroid disease, or can attack a number of different structures (systemic)
what predisposes patients to rheumatological conditions ?
its multifactorial - prob due to genetics and environmental e.g. infection, chemical exposure etc.
what condition is associated with the anti-CCP antibody associated with?
rheumatoid athritis
what antibody are the following conditions associated with ?
SLE, Sjogrens syndrome, Systemic sclerosis, MCTD, autoimmune liver disease
Anti-nuclear antibody (ANA)
what condition is both of these antibodies associated with?
- Anti-double stranded DNA antibody (dsDNA)
- Anti-Sm
SLE - systemic lupus erythematosus
what 2 conditions is associated with Anti-Ro antibody?
SLE, sjorgens syndrome
what condition is Anti-centromere antibody associated with?
Systemic sclerosis (limited)
what condition is Anti-Scl-70 antibody associated with ?
Systemic sclerosis (diffuse)
what conditions is Anti-RNP antibody associated with ?
SLE, Mixed connective tissue disease (MCTD)
what condition is Anti-Jo-1 antibody associated with?
Myositis
what condition is Anti-cardiolipin antibody and lupus anti-coagulant
Anti-phospholipid syndrome
what conditions is Anti-neutrophil cytoplasmic antibody (ANCA) associated with?
Small vessel vasculitis (GPA, EGPA, MPA)
match the antibodies to there associated conditions:
- Anti-CCP antibody
- Anti-nuclear antibody (ANA)
- Anti-double stranded DNA antibody (dsDNA) also called Anti-DNA binding
- Anti-Sm
- Anti-Ro
- Anti-La
- Anti-centromere antibody
- Anti-Scl-70 antibody
- Anti-RNP antibody
- Anti-Jo-1 antibody
- Anti-cardiolipin antibody and lupus anti-coagulant
- Anti-neutrophil cytoplasmic antibody (ANCA)
- Small vessel vasculitis (GPA, EGPA, MPA)
- Anti-phospholipid syndrome
- Systemic sclerosis (diffuse)
- Systemic sclerosis (limited)
- SLE, Mixed connective tissue disease (MCTD)
- Myositis
- Sjogrens syndrome
- SLE
- Rheumatoid arthritis
- SLE, Sjogrens syndrome
- SLE, Sjogrens syndrome, Systemic sclerosis, MCTD, autoimmune liver disease
- SLE
- Rheumatoid arthritis
- SLE, Sjogrens syndrome, Systemic sclerosis, MCTD, autoimmune liver disease
- SLE
- SLE
- SLE, Sjogrens syndrome
- Sjogrens syndrome
- Systemic sclerosis (limited)
- Systemic sclerosis (diffuse)
- SLE, Mixed connective tissue disease (MCTD)
- Myositis
- Anti-phospholipid syndrome
- Small vessel vasculitis (GPA, EGPA, MPA)
what type of condition is osteoarthritis ?
degenerative condition - sometimes there is associated swelling which can cause flare ups of OA (remember it itself is not an inflam rheumatoid condition though).
Generally it is accepted that there is an imbalance between wear and repair of cartilage within joints.
when there is no known causative facotr causing the OA what is the classed as ?
primary OA
when there is causative factors causing the OA what is it known as ?
secondary OA
what are some of the causes of secondary OA?(10)
- Congenital dislocation of the hip
- Perthes
- SUFE
- Previous intra‐articular fracture
- Extra‐articular fracture with malunion
- Osteochondral / hyaline cartilage injury
- Crystal arthropathy
- Inflammatory arthritis (can give rise to mixed pattern arthritis)
- Meniscal tears
- Genu Varum or Valgum
what mneunmonic do use to assess an X-ray for OA ?
LOSS
L- loss of joint space
0- Osteophytes
S - Sclerosis
S - Subchondral cysts
what is the management of OA?
Simple analgesia and mild opiates may be helpful. Physiotherapy is useful in strengthening surrounding structures. Weight loss and exercise are also important.
In some situations surgery may be an option e.g. hip and knee replacement, but this depends on the joint affected.
what 4 broad categories can inflammatory conditions be classed into?
seropositive, seronegative, infectious and crystal deposition disorders.
what are many of the inflammatory arthropathies due to ?
Due to auto‐immune mediated conditions where the patient’s own immune system attacks the joints and sometimes the connective tissues of the musculoskeletal (and other) systems.
what mainstay for treatment of inflammatory arthropathies ?
Simple analgesia, anti‐ inflammatory medications (steroids & NSAIDs), steroid injections and Disease Modifying Anti Rheumatic Drugs (DMARDs).
describe the joint involvement in osteoarthritis
describe the joint involvement in rheumatoid arthritis
describe the joint involvement in psoratic arthritis
describe the joint involvement in inflammatory spondylitis