PATHOLOGY Flashcards
Most common cause of cellular injury
Hypoxia
The irreversible condensation of chromatin in the nucleus of a cell undergoing necrosis or apoptosis
Pyknosis or karyopyknosis
Fragmentation of nucleus
Karyorrhexis
Disintegration and dissolution of a cell nucleus when a cell dies
Karyolysis
Refers to conditions caused by exposure to chemical or physical agents in the ambient workplace and personal environment, including diseases of nutritional origin
Environmental disease
Studies the distribution, effects and mechanisms of action of toxic agents
Toxicology
Exogenous chemicals in the environment in air, water, food and soil that may be absorbed into the body through inhalation, ingestion and skin contact
Xenobiotics
Xenobiotics can be metabolized to non toxic metabolites and eliminated from the body
Detoxification
Cherry red color of mucosa
Bitter almond odor
Carbon monoxide poisoning
Carbon monoxide + hemoglobin = ?
Irreversible
Carboxyhemoglobin
Child ingesting flakes of paint
Lead poisoning
Severe abdominal pain not compatible with physical exam. Diagnosis?
Mesenteric ischemia
MC location: Griffith’s point (splenic flexure)
DOC for acute management of lead poisoning
EDTA +/- Dimercaprol
Toxicity due to contaminated fish, dental amalgams and gold mining l
Mercury poisoning
Mercury poisoning with cerebral palsy, deafness, blindness and mental retardation
Minamata disease
Due to Methylmercury
Main protective mechanism againts mercury poison
Intracellular glutathione
Poison of kings and the king of poisons
Sources: pesticides, agricultural products and burning of coal
Arsenic poisoning
Toxicity manifested as milk and roses complexion, hyperkeratosis, diarrhea, transverse bands in nails (Mee’s lines) and convulsions
Arsenic poisoning
What organ in the GI tract does not have a serosa?
Esophagus
- more prone to infection and cancer
Aschoff bodies
Vegetations
Rheumatic fever
Rokitansky aschoff bodies
Chronic cholecystitis
Anitschow cells or caterpillar cells
Aschoff bodies
Rheumatic fever
Immune response of Rheumatic heart disease
Molecular mimicry
Machinery like murmur
PDA
Holosystolic murmur with opening snap
Severe Mitral Stenosis
Native valve endocarditis (NVE)
S. Viridans
Endocarditis in IV drug users
S. Aureus
Prosthetic valve endocarditis
S. Epidermidis
Uninfected vegetations seen on patients with malignancy and chronic diseases
Marantic endocarditis
Dysphagi
Iron deficiency anemia
Esophageal webs
Plummer vinson
Excess iodide intake initially increases organification but this is later followed by supression
Wolf chaikoff effect
Iodine induced hyperthyroidism
Hyperthyroidism following administration of iodine or iodide either as a dietary supplement or as a contrast medium
Jod basedow phenomenon
Thyrotoxicosis
Ophthalmopathy
Dermopathy
Graves disease
Most common cause of hypothyroidism in iodine sufficient areas of the world
Autoimmune hypothyroidism
Chernobyl
Papillary thyroid carcinoma
Thyroid cancer: calcitonin
Medullary thyroid carcinoma
Pathogenesis:
Failure of the mechanisms that maintain self- tolerance
SLE
Most common etiology of Hypertension
Primary or essential hypertension
Most common etiology of Secondary Hypertension
Renovascular hypertension
approximate weight of the heart in the average adult male
300 to 360 grams
Female : 250 to 320 grams
A chronic process involving damage to endothelium and the build up of vessel-occluding lesions called plaque
Atherosclerosis
Most common cause of myocardial ischemia
Coronary artery disease
The earliest detectable feature of myocyte necrosis
Sarcolemmal membrane disruption
What is the most important disease affecting the heart?
Coronary Heart Disease
The most abundant form of lactate dehydrogenase in the heart is:
LD1
Most cardio-specific troponin?
Trop I
Hemosiderin-laden macrophages that are telltale signs of previous episodes of pulmonary edema
Heart failure cells
Macrophages seen in placenta
Hofbauer cells
Histopathologic finding in interstitial lung disease suggestive of significant asbestos exposure (asbestosis)
Ferruginous bodies
The most common congenital cardiac malformation
Ventricular septal defect
The most common genetic cause of CHD
Down Syndrome (Trisomy 21)
The most likely gene defect in DiGeorge Syndrome
TBX1
Most common location of atrial septal defect
Near the center of the atrial septum
Most common type of Atrial Septal Defect
Ostium secundum
Most common cardiac anomaly seen in an infant presenting with mental retardation, brushfield spots and a simian crease
Endocardial cushion defect
Most common cyanotic Congenital Heart Disease
Tetralogy of Fallot
The most common manifestation in Rheumatic Fever
Migratory Arthritis
The antecedent infection associated with the molecular mimicry seen in Rheumatic Fever
Streptococcus pyogenes
Libman-sacks disease refers to
Endocarditis of systemic lupus erythematosus
The most common etiology of Myocarditis
Coxsackie B virus
Infective endocarditis associated with virulent organisms; affects previously normal valves; highly destructive; bulkier vegetations; valve perforation common
acute IE
Known as Apical ballooning syndrome, Stress cardiomyopathy or “Broken-hearted” syndrome
Takotsubo Syndrome
Peripheral manifestations of infective endocarditis
Roth’s spots
Janeway lesions
Osler’s nodes
Drug of choice for the prophylaxis of Rheumatic Fever
benzathine Penicillin
Most common location of Ventricular septal defect
Membranous interventricular septum
Oncogenes and tumor suppressor genes of Papillary Thyroid CA
RET
Most common alteration in Papillary Thyroid CA
BRAF
Oncogene and tumor suppressor gene for follicular thyroid CA
PAX8-PPARy1
Oncogene and tumor suppressor genes for Anaplastic Thyroid CA
p53
TERT, BRAF and CTNNB1
Guardian of the genome
p53
BRAF mutation
- loss of iodine uptake by tumor cells
- increase recurrence rate
Most common type of thyroid CA
Well differentiated thyroid malignancy
Orphan Annie eyes/ clear cell nuclei
Papillary thyroid CA
Most common thyroid cancer seen in iodine deficient regions
Capsular and or vascular invasion
Hurtle cell histology
Follicular thyroid Ca
Hallmark of intestinal metaplasia
+ of goblet cell
Drug that causes gingival hyperplasia
Phenytoin
Most common cause of death of young athletes
Hypertrophic obstructive cardiomyopathy
Acute cause of Right Ventricular Hypertrophy
Pulmonary embolism
First sign of puberty in girls
Thelarch/ breast bud
8 yr/old
Virchow’s triad?
Stasis
Increased vascular permeability
Hypercoaguability
Earliest manifestatiob of almost all forms of injury to cell
Cellular swelling
Pro-apoptotic proteins
Bax
Bad
Bak
Anti-apoptotic
Bcl-2
Necrosis in solid parenchymal organs like heart and kidney that preserves architecture and with ghost cells
Coagulative
Necrosis in brain (acute cerebral infarct) abscess and pleural effusion
Liquefactive
Necrosis in TB granuloma with lysed cells surrounded by inflammatory cells
Caseation
Necrosis in pancreas and adipose tissues
Fat necrosis
Necrosis in arteries
Fibrinoid necrosis
Necrosis in DM foot
Gangrenous necrosis
A genetically controlled form of cell death that resembles necrosis morphologically but like apoptosis genetically.
Ligation of TNFRI
Necroptosis