ANATOMY and HISTOLOGY Flashcards
Macrophage in brain
Microglia/ glial cells
Macrophage in liver
Von kupffer cell
Macrophage in placenta
Hofbauer
Macrophage in lungs
Alveolar macrophage
The bulbus cordis becomes what structure in the adult heart?
Right ventricle
Plane of the abdomen is described as being halfway between suprasternal notch and pubic symphysis (L1 vertebra level in erect position)
Transpyloric
Muscular aponeuroses form the conjoint tendon
External oblique and internal oblique
In which abdominal layer is the opening of the deep inguinal ring is located
Transversalis fascia
Hernias presents as a bulge on the Hesselbach’s triangle
Direct hernia
Muscular aponeuroses contribute to the anterior rectus sheath above the arcuate line of Douglas
External and internal oblique muscles
Supplies cutaneous innervation to the umbilicus
T10
LINES will be directly traversed by an incision passing between 2 rectus abdominis muscles
Linea alba
Type of hernia arises when the bowel and peritoneal sac protrudes through the deep inguinal ring and enter the inguinal canal
Indirect
Spinal nerves will NOT enter the rectus sheath
L1
Muscular valve controls the flow of digestive juice from the pancreatic and common duct to duodenum
Sphincter of Oddi
artery of origin of the vasa brevia or short gastric arteries
Splenic
vertebral level does the esophagus start
C6
direct branch of the celiac trunk
Left gastric
Common hepatic
Splenic
Where are the spiral valves of Heister located
Cystic duct
Which part of the large intestine is the MOST prone to rupture in cases of complete intestinal obstruction
Cecum
artery runs in the superior border of the pancreas
Splenic
surfaces of the rectum is devoid of peritoneum
Lower third, anterior surface
vertebral level corresponds to the start of the rectum
S3
intestinal segments will LEAST likely develop necrosis with superior mesenteric artery thrombosis
Rectum
Most common pituitary gland tumor in adults
Prolactinoma
Most common pituitary gland tumor in children
Craniopharyngioma
Part of the vertebrae that supports majority of the weight
Lumbar
Biggest vertebral body
Fused regions of the vertebrae
Sacral (5)
Coccygeal (4)
Most distinctive feature of each cervical vertebra
Foremen transversarium / transverse foramen
Normal embryology of the breast
Modified apocrine sweat gland
Functional unit of breast
Terminal duct lobular unit (TDLU)
2 cell types that will line the ducts and lobules of the breast
Myoepithelial cells (contractile)
Luminal epithelial cells
2 types of stroma of the breast
Interlobular stroma
Intralobular stroma (hormonally responsive)
Epithelium of nipple and arrows
Stratified squamous epithelium
Functions in nipple lubrication, becoming prominent during pregnancy
Ariel at glands (of Montgomery)
Area of highest density of breast tissue among males
Subareolar area
Area of highest density of breast tissue among females
Upper outer quadrant
Cells in seminiferous tubules
Germ cells
Sertoli cells
Cells in interstitium of testis
Leydig cells
Mature spermatocytes
Presence of Acrosomal cap
Most common birth defect of male genitalia
Cryptorchidism
Phases of testicular descent
- TRANSABDOMINAL PHASE (Mullerian inhibiting substance by Sertoli cells)
- INGUINOSCROTAL PHASE (MC arrest descent) androgen and Hcg of calcitonin related peptide from genitofemoral nerve
Weight of prostate gland
20 grams
Anatomical zone of prostate cancer
Peripheral
Perineural invasion
Anatomical zone of BPH
Transitional and the periurethral
Most common form of prostatitis
Chronic abacterial prostatitis
BPH involves hyperplasia of what type of cells
Stromal and epithelial cells
Main androgen in prostate
Dihydrotestosterone (DHT)
Main arterial vascular supply of spinal cord
Anterior Spinal Artery (ASA)
Ant 2/3 of spinal cord
(From Anterior Radiculomedullary artery)
PSA - Post 1/3
Largest radiculo-medullary artery
Between T9-T12
Artery of Adamkiewics
(Arteria radicularis magna)
Reinforces the circulation in lower 2/3 of spinal cord
2nd largest artery
Enters central canal at the C5-C6 vertebral level
Artery of Cervical Enlargement
Communication of basivertebral veins and the posterior external vertebral venous plexus
Batson’s plexus
Responsible for metastasis of:
Breast CA, prostate CA, vertebral column, brain
Right and left vertebral veins will become …..
Basilar veins
Space between dura and wall of vertebral canal
Epidural space (extradural)
Contains internal vertebral venous plexus
Contains FAT
Between arachnoid and pia mater
Spinal cord ends at L1/L2
Dura ends at S2
Subarachnoid space
Contains CSF
Terminal portion of spinal cord
Conus medullaris
Blood supply of spinal cord (3A 1V)
Anterior spinal arteries (ASA)
Posterior spinal arteries (PSA)
Radicular Arteries (RA)
drain into:
Internal Vertebral Venous Plexus
Fibrous extension of the pia mater; anchors the spinal cord to coccyx
Filum terminale
Collection of nerve roots at the inferior end of the vertebral canal
Cauda equina
3 veins that contribute to Batson’s Venous Plexus
Internal vertebral venous plexus
External vertebral venous plexus
Basivertebtal veins
Hemisection of cord
Ipsilateral loss of touch and vibration
Contralateral loss of pain and temp
Brown sequard syndrome
Complete paralysis from the level of trauma
Hyperesthesia at level of the lesion
Loss of pain and temp
Proprioception is preserved
Anterior cord syndrome
Produces greater weakness of the arms than the legs
Sensory sparing is present
Central cord syndrome
Involvement of proprioception - position and vibratory sensation
Retain pain and temp sensation
Posterior cord syndrome
Slow degeneration of the dorsal/ posterior columns of the spinal cord
Loss of vibration and position sense
Tabes dorsalis
Tertiary syphilis
Pathognomonic sign of tabes dorsalis
Argyll robertson pupil
“It accomodates but does not react”
Most common spinal cord syndrome
Disproportionate UE weakness and less severe LE weakness, sensory and bladder dysfunction
Central cord syndrome
Loss of pain and temp in dermatomal distribution
“Suspended sensory level”
Girdle syndrome of central cord syndrome
Best prognosis of the spinal cord syndromes
Brown sequard syndrome
Worst prognosis of the spinal cord syndromes
Anterior corf syndrome
Least common of the spinal cord syndromes
Posterior cord syndrome
Injury to the cord at level of L1 to L2
Early sensory deficit (saddle distribution)
Bladder and bowel dysfunction
Conus medullaris syndrome
Injury that involves the nerve roots of the cauda equina and spares the spinal cord itself
Disc herniation and burst fractures
Bladder and bowel dysfunction later in the course
Cauda equina syndrome
Results from demineralization of bones
Elderly
Postmenopausal
Osteoporosis
Most common affected areas of osteoporosis
Neck of femur
Bodies of vertebrae
Metacarpals
Radius
Findings in osteoporosis
Wedge like lesion
Vertical striations
Collapsed vertebral column
Common in adolescent athletes involved in sports requiring repeated spinal HYPEREXTENSION
L5
Fracture of PARS INTERARTICULARIS
Degenerative/ traumatic defect of POST. NEURAL ARCH
Spondylolysis
“Neck of scottie dog”
Bilateral pars interartucularis defect
Forward displacement of vertebral body
L5-S1
“Slippage of vertebra anteriorly”
Spondylolisthesis
Fracture or dislocation of C1 (atlas)
Vertical compressive force
Jefferson’s fracture
Fractures involving C1, C2 and C3
Quadriplegia
Arrest of respiration
High cervical fracture
Fracture or dislocation of C2 (w/ dens of axis)
Traumatic spondylolisthesis
Sudden hyperextension
Hangman’s fracture
Hyperextension injury
Rear-end automobile collision
Strain/ torn anterior longitudinal ligament
Whiplash injury
Hyperflexion of the neck
Posterior subluxation of vertebral body
Teardrop fracture
Fracture of C7 (cervical prominence)
Clay shoveller’s fracture
Surgical excision of one or more spinous processes and the adjacent supporting vertebral laminae in a particular region of the vertebral column
Laminectomy
Umbilicus
Structures?
Vertebral level?
Dermatomal level?
AOG?
Bifurcation of the aorta
Iliac crest
V —- L4
D —- T10
AOG — 20 weeks
Structures at subcoastal plane L3
3rd part of duodenum
Origin of IMA
Transpyloric plane L1 structures
Pylorus of stomach
Duodenojejunal junction
Neck of pancreas
Hilum of kidneys
Fascial layers
Superficial
- campers (fatty)
- scarpa (membranous)
—– dartos (scrotum)
—– colles (perineum)
Extravasated urine it will be found in?
Superficial perineal space
Rupture of inferior epigastric vein
MCC is trauma
MC on the right side below umbilicus
Rectus sheath hematoma
Palpable abdominal mass that remains unchanged with contraction
Fothergill sign
Rectus sheath hematoma
2-3cm above the clavicle anterior to C6 transverse process
Most superficial passage for the brachial plexus
Erb’s point
Brachial plexus starts at? Ends?
Start - C5
End - T1
Affects C5 and C6
Waiter’s tip
Erb’s palsy
Upper brachial plexus
C8 - T1 lower brachial plexus palsy
Klumpke’s palsy
Wrist drop
Saturday night palsy
Loss of extensuon of fingers, thumb and wrist
Numbness over 1st dorsal intraosseous muscles
Radial nerve
Humeral mid-shaft fracture
Radial nerve
Ape hand
Atrophy of thenar eminence
Median nerve
Carpal tunnel syndrome
Median nerve
Pope’s blessing
Median nerve injury
PE for carpal tunnel syndrome
Tinel’s sign
- tap
Phalen’s sign
- “pray”
Nerve supplies the serratus anterior
Winging of scapula
Long thoracic nerve
Fracture of the surgucal neck of humerus
Axillary nerve injury
Quadrangular space boundaries
Sup - subscapularis
Lat - humerus
Inf - teres major
Med- triceps (long head)
Quadrangulat space contents
Axillary nerve
Posterior humeral circumflex
Axillary nerve injury
Injury to quadrangular space
Ill-fitted crutches
Radial nerve injury
Axillary nerve injury will lead to
Deltoid atrophy
Ulnar nerve injury
Claw hand
Thoracodorsal nerve
Middle subscapular nerve
Latissimus dorsi
Muscles of rotator cuff
Supraspinatus
Infraspinatus
Subscapularis
Teres MINOR
SITS
When pinching a piece of paper between thumb and index finger, the thumb IP joint will flex if the ADDUCTOR POLLICIS muscle is weak
Froment’s sign
Ulnar nerve injury
Finkelstein sign
De quervain’s tenosynovitis
Chest pain referred to medial side of arm and armpits
Intercostobrachial nerve T2
Volkmann’s contracture
Supracondylar fracture
Permanent flexion contracture of the hand and wrist (claw like deformity )
Thickening of palmar aponeurosis
Dupuytren’s contracture
Seen in uremia
Lateral epicondylitis
Tennis elbow
Medial epicondylitis
Golfer’s elbow
Cubital fossa boundaries
Base - line connecting lateral to medial epicondyle
Lat - brachioradialis
Med - pronator teres
Axillary artery –> radial artery (anatomical snufbox) —> ulnar artery
Fascial compartment of thigh : Anterior thigh muscles
supplied by FEMORAL N
— flexors of thigh, extensors of knee
Iliopsoas
Tensor fascia lata
Sartorius
Quadriceps femoris
Landmarks of anterior thigh
Anterior superior iliac spine
Anterior inferior iliac spine
Ischial tuberosity
Fascial compartment of thigh : medial thigh muscles
supplied by OBTURATOR N
— adducts the thigh
Pectinus
Adductor longus
Adductor brevis
Adductor magnus
Gracillis
Adductors LBM + P, G
Fascial compartment of thigh : posterior thigh muscles
supplied by SCIATIC NERVE
— Extensors of the thigh, flexor of leg
Hamstring muscles:
Semitendinosus
Semimembranosus
Biceps femoris
Adductor magnus
Landmarks of posterior thigh
Lesser trochanter
Linea aspera —- adductor magnus
Compartment syndrome
MC site - ANTERIOR
Increase production of fluid
Early sign - paresthesia between the 1st and 2nd toes
Treatment:
30-45 mmhg close monitoring
>45 mmhg —- surgery — fascioyomy
Femoral triangle
Triangular fascial space in the superoanterior third of the thigh
Sup - Inguinal ligament
Med - Adductor longus
Lat - Sartorius
Contents of femoral triangle
Femoral Nerve and its branches
Femoral Sheath and its contents
Femoral Artery and its branches
Femoral Vein and its tributaries
Funnel shaped fascial tube formed by inferior prolongation by inferior prolongation of iliopsoas and transversalis fascia of the abdomen
Femoral sheath
Lateral - Femoral A
Intermediate - Femoral V
Medial - Femoral Canal
Appears as a mass, often tender, in femoral triangle
Femoral hernia
Femoral ring is a weak area in anterior abdominal wall that normally admits the tip of 5th digit
MC in females
Neck of sac always LATERAL and BELOW the pubic tubercle
Most common type of hernia
Indirect hernia
Most common type of hernia in females
Indirect hernia
A fascial tunnel in the thigh running from the apex of femoral triangle to the adductor hiatus in the tendon of adductor magnus muscle
Adductor canal / subsartorial canal / hunter’s canal
Boundaries and contents of adductor canal
Ant - Sartorius
Lat - Vastus medialis
Post & Med - adductor longus / magnus
Contents:
- Femoral A/V
- Saphenous N
- Nerve to Vastus Medialis
Gluteal muscles
Gluteus Maximus
Gluteus Medius
Gluteus Minimus
Movement of Gluteus Maximus
Nerve supply?
Extension
Inferior gluteal nerve
Movement of Gluteus Medius
Abduction
Action of Adductor Magnus
Adduction
Action of Gluteus Minimus and Tensor Fascia Lata
Nerve supply of Gluteus Minimus?
Medial rotator
Superior Gluteal Nerve
Movement of Obturator Internus
Lateral rotator
Movement of Iliopsoas
Flexion
Most common cause of sciatic nerve injury
Intragluteal Injection
Upper outer quadrant = avoid!!
7 bones of the orbit
Frontal
Lacrimal
Ethmoidal
Zygomatic
Maxillary
Sphenoidal
Palatine
Fracture of the walls or floor of the orbit
Blow out fracture
Opacification in xray
Periorbital fat and possibly an entrapped extraocular muscle in the maxilary sinus
Teardrop sign
Pan-faced deformity in Lefort
Craniofacial dysjunction
High level fractures
Lefort III
Transverse maxillary fractures
Low level
Guerin type fracture
Floating fracture
Le fort I fracture
Pyramidal fractures
Separates maxilla from the face
Le fort II
Zygomaticomaxillary complex fractures
Including lateral orbital wall, inferior orbital floor
Zygomatic arche
**widening of zygomatico frontal suture
Tripod/ malar fractures
Most common part of the mandible fractures
Condylar process
The misalignment of teeth and jaws or more simple a bad bite
Malocclision
Layers of the skin
Epidermins - thin outer layer
Dermis/ corium - thick underlying layer
Hypodermis - fatty layer
Layers of the Epidermis
From basal lamina to free surface:
- S. Germinativum/ basale
- S. Spinosum
- S. Granulosum
- S. Lucidum
- S. Corneum
Carlos Loves Girls in String Bikinis
Most abundant cells in the epidermis
Keratinocytes
Contains keratin
Cells located in the basal cell layer
- Melanocytes
- Merkel cells / merkel ranvier (tactile epithelial cell for light touch)
- Basal cells
Outermost layer of the epidermis
Stratum corneum
W/ mostly DEAD CELLS filled with KERATIN
The “horn layer” of the epithelium
Water resistant
Shed and replaced every 2 weeks
Stratum corneum
The formation of layer of dead, protective cells filled with keratin
Occurs in all exposed skin except EYES
Keratinization
Translucent skin layer
“Clear layer”
May not exist in thinner skin
Dead layer
Covers s. granulosum
Stratum Lucidum
1 or more layers of cells starting to die and become hard. Keratinization…. becoming FIBROUS PROTEIN similar to that in HAIR and NAILS
Stratum granulosum
Layer capable of CELL DIVISION
Innermost layer of epidermis
Contains MELANIN
Stratum germinativum/ basale
The “Grainy layer”
Stops dividing, starts producing:
- Keratin (tough, fibrous, hair and nails)
- Keratohyalin (dense granules-lipids, crosslinking fibers)
Stratum Granulosum
Keratohyaline contains
Histidine and cysteine rich proteins with lipids
The “Spiny layer”
8-10 layers of keratinocytes bound by desmosomes
Cells shrink until cytoskeletons stick out (spiny)
Startum Spinosum
Prevent epidermal cells from separating
Desmosomes or Macula Adherens
Strengten attachment to basal lamina
Hemidesmosomes
Blistering skin disease
Autoimmune disease
Targets the DESMOGLEIN of desmosomes
Pemphigus vulgaris
Where are the LANGERHANS CELLS located
Stratum Spinosum
Deepest layer of epidermis
Layer closest to blood supply
Stratum Germinativum/ basale
Most common acquired disease of hemidesmosomes
Basal Lamina
Bullous pemphigoid
Structures of stratum germinativum
Epidermal ridges (fingerprint)
Dermal papillae (tiny mounds)
4-6 months fully developed fingerprints!
Caused by staph aureus
Exfoliatin
Splitting of the skin
Staphylococcal Scalded Skin Syndrome (SSSS)
Honey crusted lesion
Impetigo
(Strep pyogenes)
Most severe form of SSSS
Ritter’s Disease
Lyell’s disease
TEN (Toxic Epidermal Necrolysis)
Gives the skin the orange-yellow pigment
Can be converted to Vit A
Carotene
Yellow brown or black pigment
Produced by melanocytes in s germinativum
Stored in MELANOSOMES
Melanin
Defective excision repair which leads to production of thymidine dimers
Xeroderma Pigmentosum (XP)
Loss of melanocytes (autoimmune, neurohumoral, or self destruction of melanocytes)
Vitiligo
Absence of melanin pigment in melanocytes (lack of defect in tyrosinase)
Albinism
Macules in lightly pigmented individuals, increased pigment in basal keratinocytes
Freckles
Mask-like zone of facial hyperpigmentation due to enhanced pigment transfer to basal keratinocytes or dermal macrophages
Melasma
Causes:
OCP
Pregnancy
Thyroid disorder
Endocrine disorder
Localized hyperplasia of melanocytes, often seen in infancy and childhood
Lentigo
Bluish tint of skinsevere reduction in blood flow or oxygenation
Cyanosis
Icteric sclerae
2-3mg/dl
Yellow color
Jaundice
Most active form of vitamin D
1,25 dihydroxycholecalceferol
Powerful peptide growth factor used to grow SKIN GRAFTS. Produced by salivary and duodenum
Epidermal Growth factor (EGF)