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Patho 2 > Patho Of MS > Flashcards

Patho Of MS Flashcards

1
Q

Immune-mediated inflammatory disease of the CNS

A

Multiple Sclerosis

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2
Q

Activate peripheral t-cells breach____ and release chemicals to rally

A

Blood brain barrier

Immune system forces

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3
Q

MS ____x higher for person with affected relative

F:M ratio

A

10-50 x

3 women-1 men

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4
Q

Approximately 55-75% of pts have _____ at some point duringg course of disease

A

Spinal cord lesion

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5
Q

Optic nerve involvement and myelopathy

A

Neuromyelitis optica

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6
Q

Different MS classifications

A

Relapsing remitting MS
Secondary progressive MS
Primary progressive MS
Malignant MS

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7
Q

Accute attacks with full recovery

How many ppl Dx with this form initially?

A

Relapsing remitting MS (RRMS)

85%

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8
Q

Starts with RRMS followed by progression at variable rate with relapses and plateus

A

Secondary Progressive MS (SPMS)

50% of ppl with RRMS get it

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9
Q

Progression of disability from on w/ or w/o plateau, remission, improvement

Who has worst prognosis

A

Primary progressive MS (PPMS)

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10
Q

Progression from onset but clear acute relapses

A

Progressive Relapsing MS (PRMS)

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11
Q

Rare and results in death

A

Malignant MS

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12
Q

Symptoms lasting for more than 1-2 days

A

Relapse

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13
Q

What causes the axonal damage in MS

A

Inflammation

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14
Q

Dx of MS is based on

A

Med history

Signs + Symptoms

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15
Q

Lesions of MS are ____ and involve

A

Deep in brain and involve white matter (plaque)

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16
Q

MS lesions grouped into

A

4 patterns

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17
Q

Quantifies disability in 8 Functional Systems

A

Expanded Disability Status Scale (EDSS)

18
Q

EDDS of 1-4.5 refer to MS that is ___

5-9.5 is

A

Fully ambulatory

Impaired ambulation

19
Q

Symptoms of MS

A 
Fatigue
Pain
Impaired ambulation
bowel/bladder
Motor impairments (just a summarization)
20
Q

Factors of favorable prognosis

A 
Female
<35 y/o
Monoregional
Sensory vs motor
Recovery after exacerbation
21
Q

Less favorable Prognosis of MS

A 
Male
>35
Cerebellar symptoms
Decreased recovery
African-American
22
Q

2 aspects of medication Tx for MS

A

Immunomodulatory Therapy

Symptom Modifying

23
Q

Disuse process that occurs slowly and unnoticed..

Decreased by exercise

A

Creeping diability

24
Q

Pts with MS have __ less aerobic capacity

A

30%

25
Q

PT focus for MS is to

A

Improve and maintain Function

26
Q

Most common symptom of MS

A

Fatigue

27
Q

Fatigue caused by factors related to the disease

A

Primary fatigue

28
Q

Fatigue caused by pathological consequences of diseaase

A

Secondary Fatigue

29
Q

Subjective fatigue with mental fatigue/ axon damage/Reduced glucometabolism

Disorder of central, peripheral, and autonomic NS

A

Central Fatigue

30
Q

Disorder of muscle and neurmuscular junction
Disuse
Impaired calcium
Impaired excitation

A

Peripheral fatigue

31
Q

Central and peripheral fatigue can

A

Coexist

32
Q

Disease modifying drugs used for:

Exercise used for:

A

Central fatigue

Peripheral Fatigue

33
Q

Fatigue in MS patients may be reduced by increasing:

A

Oxidative Capacity of Skeletal muscle

34
Q

Treatment for one problem can

A

Aggravate another

35
Q

Encourage balance and endurance training before someone has begun to experience falls

A

Over-rehab

36
Q

Body core tempt lowest in

A

Morning

37
Q

Best modality for MS

A

Air dyne

38
Q

When is fatigue symptom from exercise normalized

A

30 minutes

39
Q

Reduction of visual activity and increased fatigue associate with hyperthermia

A

Uhthoff’s Phenomenon

40
Q

Fracture risk of pts with MS compared to norm

A

2-3.4x

Patho 2 (14 decks)

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