Guillain Barre

Question 1

• Autoimmune disorder (antibody mediated demyelination)

* Myelin sheath on peripheral nerves is attacked causing demyelination

Answer 1

GBS

Question 2

When is max weakness for GBS

Answer 2

2-3 weeks post onset

Question 3

What is spared allowing for future recovery & re-myelination

Answer 3

Schwann cells

Question 4

What is GBS associated with prior to obatining?

Answer 4

Infection

Question 5

Surgery for GBS?

Answer 5

Renal transplant

Question 6

Progression of GBS is

Answer 6

Fast (2-4 weeks)

Question 7

GBS starts as ____ presentation

Answer 7

Stocking glove, bilateral

Question 8

Increased protein in the cerebrospinal fluid without increase in white blood cell count

Answer 8

Albuminocytologic dissociation

Question 9

Dx criteria for GBS

Answer 9

Progressive symmetric weakness
Sensory deficit
Loss of DTR
Tachycardia/arrythmia
Absence of fever
EPS of demyelination
CSF reveals low WBC and ^ protein

Question 10

The process of removing plasma from the circulatory system and filtering it in order to remove antibodies

Answer 10

Plasmapheresis

Question 11

How often is plasmapheresis performed?

Answer 11

4-6x in 1 week

Question 12

2 medical treatments in GBS

Answer 12

Plasmapheresis

Intravenous immunoglobulins

Question 13

When does recovery begin?

Answer 13

2-4 weeks post peak impairment

Question 14

Good prognostic indicators?

Answer 14

Young
Less time b/w peak and recovery
Degree of impairent
No mechanical vent

Question 15

•Considered the chronic counterpart to classic type of GBS

Answer 15

Chronic inflammatory Demyelinating polyneuropathy

Question 16

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

Progression?

And what does it require for Dx

Answer 16

slow (>8 weeks-year)

Nerve biopsy

Question 17

Tx of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

Answer 17

Corticosteroids with immunosuppressant drugs
Plasmapheresis
IV immunoglobulin