Osteoporosis Flashcards
OP most common in
Women
Morbidity and mortality in men and women
Men: 30%
Women 9%
Collagen is ___ and provides
Protein
Soft framework
Calcium phosphate is ___
What does it do?>
Mineral
Add strength and harden framwork
Cortical bone characteristics
Outer shell
Shaft
80% of skeletal mass
Cancellous/spongy trabecular bone characteristics
Inner part of bone, end of long bone
20% mass
Process of bone remodeling is
Resorbtion and formation of bone
Cells that break bone down
Whats lifespan?
Osteoclasts
3 weeks
Cells that form new bone and life span
Osteroblasts
3 months
What responds to mechanical strain by sending signals to osteoblasts to increase bone formation or osteoclasts to remove?
Osteocytes
How does osteoporosis occur?
Mismatch b/w osteoblasts/clasts
What are other factors of osteoporosis
Change in hormone postmenopause
Low calcium and vitamin D
Largest amount of bone tissue person has in their life
Peak bone mass
Peak bone mass attained @ what ages?
18 girls
19/20 guys
Growth spur occurs at what ages and how much of total bone mass is accumulated in this period?
11-14 for girls
13-17 for guys
40%
What are the 3 types of Osteoporosis?
Generalized
Regional
Localized
OP that involves the whole skeleton
Generalized OP
OP of limb or region of skeleton
Regional OP
OP involving focal areas of bone
Localized OP
Bone loss associated with biological changes that occur during life span
Primary OP
2 types of primary OP and association
Type 1: post menopause decreased estrogen
Type 2: aging process
OP that occurs at any age
Secondary OP
Bone loss in secondary OP characterized by
Med. conditions
Malnourished
Meds
Immob
“ACCESS leads to OP
Alcohol use Corticosteroid Calcium low Estrogen low Smoking Sedentary life
