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✅Patho-Neoplasia Flashcards

1
Q

Non neoplastic overgrowth of disorganized tissue indigenous to a particular site

A

Hamartoma

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2
Q

Non-neoplastic tissue in a foreign location

A

Choristoma

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3
Q

Syndrome with hamartomas

A

Peutz jeghers syndrome

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4
Q

Fibrous tissue formation in response to neoplasm

A

Desmoplasia

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5
Q

Mutations cause sustained activity of genes

A

Proto-oncogenes

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6
Q

Mutations cause unregulated cell proliferation

A

Tumor suppressor genes

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7
Q

Name the protooncogene involved.

CML

A

Abl

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8
Q

Name the protooncogene involved.

Burkitt’s lymphoma

A

C-myc

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9
Q

Follicular and undiferrentiated lymphomas

A

Bcl-2

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10
Q

Name the protooncogene involved.

Breast, ovarian and gastric carcinomas

A

Erb-B2

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11
Q

Name the protooncogene involved.

Colon carcinoma

A

ras

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12
Q

Name the protooncogene involved.

Lung cancer

A

L-myc

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13
Q

Name the protooncogene involved.

Neuroblastoma

A

N-myc

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14
Q

Name the protooncogene involved.

MEN II and III

A

Ret

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15
Q

Name the protooncogene involved.

GIST

A

C-kit

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16
Q

Name the tumor suppressor gene and chromosome involved:

Retinoblastoma, osteosarcoma

A

Rb 13q

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17
Q

Name the tumor suppressor gene and chromosome involved:

Breast and ovarian cancer

A

BRCA1 17 mq

BRCA2 13q

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18
Q

Most human cancers, li-fraumeni syndrome

A

P53

17p

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19
Q

Name the tumor suppressor gene and chromosome involved:

Melanoma

A

P16

9p

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20
Q

Name the tumor suppressor gene and chromosome involved:

Colorectal CA associated with FAP

A

APC 5q

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21
Q

Name the tumor suppressor gene and chromosome involved:

Wilm’s tumor

A

WT1

11p

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22
Q

Name the tumor suppressor gene and chromosome involved:

NF1 and NF2

A

NF1 17q

NF2 22q

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23
Q

Name the tumor suppressor gene and chromosome involved:

Pancreatic ca

A

DPC 18q

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24
Q

Name the tumor suppressor gene and chromosome involved:

Colon cancer

A

DCC 18q

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25
TNM staging is more for
Prognostication
26
Cancers in children
ALL CNS Burkitt's lymphoma
27
Cancers in men
Prostate Lung Colorectal
28
Cancers in women
Breast Lung Colorectal
29
Cancers that cause the most mortality in men
Lung Prostate Colorectal
30
Cancers that cause the most mortality in women
Lung Breast Colorectal
31
Malignant tumors ending with "oma"
Hepatoma | Seminoma
32
What are the malignancies associated wity tuberous sclerosis
Astrocytoma Angiomyolipoma Cardiac rhabdomyoma
33
Malignancy associated with actinic keratoses
SCCA
34
Malignancy assoc with plummer vinson syndrome
SCCA of the esophagus
35
Malignancy associated with paget's disease of the bone
Secondary osteosarcoma | Fibrosarcoma
36
Malignancy asociated with immunodeficiency states
Malignant lymphoma
37
Malignancy associated with autoimmune diseases
Lymphoma
38
Malignancy assoc with acanthosis nigricans
Visceral malignancy
39
Malignancy assoc with radiation exposure
Sarcoma | Papillary thyroid CA
40
Most common cancers in China | Identify the cause.
Nasopharyngeal CA due to EBV
41
Most common cancers in Japan | Identify the cause.
Gastric adenoca | Smoked food
42
Most common cancers in SEA | Identify the cause.
HCCA | HBV and aflatoxin
43
Aflatoxin is from
A. Flavus
44
Most common cancers in Africa | Identify the cause.
Burkitt's lymphoma | EBV
45
Cachexia in CA is due to
TNF alpha
46
What are paraneoplastic syndromes
Distant effects of a tumor unrelated to metastasis
47
Chemical carcinogens Vinyl chloride
Liver abgiosarcoma
48
Chemical carcinogens CCl4
Centrilobular necrosis, fatty liver
49
Chemical carcinogens Nitrosamines
Esoohagus stomach CA
50
Chemical carcinogens
Bronchogenic CA | Mesothelioma
51
Chemical carcinogens Arsenic
SCCA skin | Liver angiosarcoma
52
Chemical carcinogens Naphthalene (aniline) dyes
Transitional cell ca bladder
53
Chemical carcinogens Alkylating agents
Blood (leukemia)
54
Associated cancer and infectious agent Liver fluke
Cholangiocarcinoma Chlonorchis sinensis Opisthorchis viverrini
55
Associated cancer and infectious agent Peptic ulcer disease
Gastric adenoca MALT lymphoma H pylori
56
Associated cancer and infectious agent Chronic cystitis
Bladder SCCA Schistosoma haemotobium
57
What CA of the lung is notorious for endocrinopathies?
Small cell cA Acth adh pthrp
58
Name the clinical syndrome of the underlying cancer Lung CA
Lanbert-eaton myasthenia
59
Name the clinical syndrome of the underlying cancer Visceral ca
Acanthosis nigricans
60
Name the clinical syndrome of the underlying CA Pancreatic CA
Trousseau syndrome
61
Name the clinical syndrome of the underlying CA Thymoma
Red cell aplasia
62
Name the clinical syndrome of the underlying CA Hodgkin's lymphoma
Nephrotic syndrome
63
Electrolyte abnormalities in tumor lysis syndrome
Hyperkalemia Hyperuricemia Hyperphosphatemia HYPOCALCEMIA
64
CA with brain mets
``` Lung Breast Skin (melanoma) Kidney (renal cell ca) GI ``` Mnemonic: LOTS OF BAD STUFF KILL GLIA
65
Liver metastasis occur in which CA
``` Colon Stomach Pancreas Breast Lung ``` Cancer sometimes penetrate benign liver
66
Bone mets in CA
``` Prostate (blastic) Thyroid (follicular) Testes Breast (both lytic and blastic) Lung (lytic) Kidney ```
67
Tumor marker Prostate CA
PSA
68
Tumor marker Hepatocellular CA
AFP
69
Tumor marker Colorectal CA Pancreatic , GI, breast CA
CEA
70
Tumor marker Hydatidoform mole ChorioCA GEstational trophoblastic tumor
B HCG
71
Tumor marker Ovarian Malignant epithelial CA
Ca-125
72
Tumor marker Mets to bone Obstructive biliary disease Pagets disease of the bone
Alk phos
73
Tumor marker Melanoma Neural tumors Astrocytomas
S-100
74
Tumor marker Neuroblastoma
Bombesin
75
Tumor marker Hairy cell leukemia
TRAP
76
Tumor marker Panc CA
CA 19-9

PTHO (34 decks)

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